209
AC, Chiang DY, Chirieac LR, Cho J, Fujii Y,
Gazdar AF, Giordano T, Greulich H, Hanna
M, Johnson BE, Kris MG, Lash A, Lin L,
Lindeman N, Mardis ER, McPherson JD,
Minna JD, Morgan MB, Nadel M, Orringer
MB, Osborne JR, Ozenberger B, Ramos AH,
Robinson J, Roth JA, Rusch V, Sasaki H,
Shepherd F, Sougnez C, Spitz MR, Tsao MS,
Twomey D, Verhaak RG, Weinstock GM,
Wheeler DA, Winckler W, Yoshizawa A, Yu S,
Zakowski MF, Zhang Q, Beer DG, Wistuba II,
Watson MA, Garraway LA, Ladanyi M, Travis
WD, Pao W, Rubin MA, Gabriel SB, Gibbs RA,
Varmus HE, Wilson RK, Lander ES, Meyerson
M (2007) Characterizing the cancer genome in
lung adenocarcinoma. Nature 450:893–898.
https://doi.org/10.1038/nature06358
- Xue W, Kitzing T, Roessler S, Zuber J, Krasnitz
A, Schultz N, Revill K, Weissmueller S,
Rappaport AR, Simon J, Zhang J, Luo W,
Hicks J, Zender L, Wang XW, Powers S, Wigler
M, Lowe SW (2012) A cluster of cooperating
tumor-suppressor gene candidates in chromo-
somal deletions. Proc Natl Acad Sci U S A
109:8212–8217. https://doi.org/10.1073/
pnas.1206062109
- Catenacci DV, Ang A, Liao WL, Shen J, O’Day
E, Loberg RD, Cecchi F, Hembrough T,
Ruzzo A, Graziano F (2016) MET tyrosine
kinase receptor expression and amplification as
prognostic biomarkers of survival in gastro-
esophageal adenocarcinoma. Cancer
123:1061–1070. https://doi.org/10.1002/
cncr.30437
- Kim SY, Ahn T, Bang H, Ham JS, Kim J, Kim
ST, Jang J, Shim M, Kang SY, Park SH, Min
BH, Lee H, Kang WK, Kim KM, Park W, Lee
J (2017) Acquired resistance to LY2874455 in
FGFR2-amplified gastric cancer through an
emergence of novel FGFR2-ACSL5 fusion.
Oncotarget 8:15014–15022. https://doi.
org/10.18632/oncotarget.14788
- Wiech T, Nikolopoulos E, Weis R, Langer R,
Bartholome K, Timmer J, Walch AK, Hofler
H, Werner M (2009) Genome-wide analysis of
genetic alterations in Barrett’s adenocarcinoma
using single nucleotide polymorphism arrays.
Lab Investig 89:385–397. https://doi.
org/10.1038/labinvest.2008.67
- Miller CT, Moy JR, Lin L, Schipper M,
Normolle D, Brenner DE, Iannettoni MD,
Orringer MB, Beer DG (2003) Gene amplifi-
cation in esophageal adenocarcinomas and
Barrett's with high-grade dysplasia. Clin
Cancer Res 9:4819–4825
- Albrecht B, Hausmann M, Zitzelsberger H,
Stein H, Siewert JR, Hopt U, Langer R, Hofler
H, Werner M, Walch A (2004) Array-based
comparative genomic hybridization for the
detection of DNA sequence copy number
changes in Barrett’s adenocarcinoma. J Pathol
203:780–788. https://doi.org/10.1002/
path.1576
- Pasello G, Agata S, Bonaldi L, Corradin A,
Montagna M, Zamarchi R, Parenti A, Cagol
M, Zaninotto G, Ruol A, Ancona E, Amadori
A, Saggioro D (2009) DNA copy number
alterations correlate with survival of esophageal
adenocarcinoma patients. Mod Pathol 22:58–
65. https://doi.org/10.1038/
modpathol.2008.150
- Nancarrow DJ, Handoko HY, Smithers BM,
Gotley DC, Drew PA, Watson DI, Clouston
AD, Hayward NK, Whiteman DC (2008)
Genome-wide copy number analysis in esopha-
geal adenocarcinoma using high-density single-
nucleotide polymorphism arrays. Cancer Res
68:4163–4172. https://doi.org/10.1158/0008-
5472.can-07-6710
- Choy B, Bandla S, Xia Y, Tan D, Pennathur A,
Luketich JD, Godfrey TE, Peters JH, Sun J,
Zhou Z (2012) Clinicopathologic characteris-
tics of high expression of Bmi-1 in esophageal
adenocarcinoma and squamous cell carcinoma.
BMC Gastroenterol 12:146. https://doi.
org/10.1186/1471-230x-12-146
- Davison JM, Yee M, Krill-Burger JM, Lyons-
Weiler MA, Kelly LA, Sciulli CM, Nason KS,
Luketich JD, Michalopoulos GK, LaFramboise
WA (2014) The degree of segmental aneu-
ploidy measured by total copy number abnor-
malities predicts survival and recurrence in
superficial gastroesophageal adenocarcinoma.
PLoS One 9:e79079. https://doi.
org/10.1371/journal.pone.0079079
- Lin L, Prescott MS, Zhu Z, Singh P, Chun SY,
Kuick RD, Hanash SM, Orringer MB, Glover
TW, Beer DG (2000) Identification and char-
acterization of a 19q12 amplicon in esophageal
adenocarcinomas reveals cyclin E as the best
candidate gene for this amplicon. Cancer Res
60:7021–7027
- Frankel A, Armour N, Nancarrow D, Krause L,
Hayward N, Lampe G, Smithers BM, Barbour
A (2014) Genome-wide analysis of esophageal
adenocarcinoma yields specific copy number
aberrations that correlate with prognosis.
Genes Chromosomes Cancer 53:324–338.
https://doi.org/10.1002/gcc.22143
- Rygiel AM, Milano F, Ten Kate FJ, Schaap A,
Wang KK, Peppelenbosch MP, Bergman JJ,
Krishnadath KK (2008) Gains and amplifica-
tions of c-myc, EGFR, and 20.q13 loci in the
no dysplasia-dysplasia-adenocarcinoma
sequence of Barrett’s esophagus. Cancer
Epidemiol Biomark Prev 17:1380–1385.
DNA Copy-Number in Esophageal Adenocarcinoma