Cannabinoids

526 J.M. Walker and A.G. Hohmann 3.3.4 Evidence for CB1Rs on Afferents Originating Supraspinally CB1R immunoreactivity is highly ...

Cannabinoid Mechanisms of Pain Suppression 527 effectsonA-βfiber-evoked responses (Kelly and Chapman 2001). Systemic and intrath ...

528 J.M. Walker and A.G. Hohmann 3.4.1 Role of the Periaqueductal Gray Studies of metabolically stable anandamide analogs and th ...

Cannabinoid Mechanisms of Pain Suppression 529 3.4.2 Role of Rostral Ventral Medulla Researchers have targeted synthetic cannabi ...

530 J.M. Walker and A.G. Hohmann The amygdala also plays a critical role in modulating antinociception. Microin- jection of cann ...

Cannabinoid Mechanisms of Pain Suppression 531 to identify the phenotypes of cells expressing CB2Rs, especially since levels of ...

532 J.M. Walker and A.G. Hohmann The main effect of inflammatory cells in nociception is to sensitize neurons. This occurs in th ...

Cannabinoid Mechanisms of Pain Suppression 533 relationship between pain circuits, exogenous drugs, and CBRs provide a founda- t ...

534 J.M. Walker and A.G. Hohmann occur in the vicinity of CBRs, with both processes leading to increased occupation of CBRs. Bel ...

Cannabinoid Mechanisms of Pain Suppression 535 forskolin-stimulated cyclic AMP (cAMP) and electrically evoked contractions of th ...

536 J.M. Walker and A.G. Hohmann 5.5 Virodhamine O-Arachidonoylethanolamine was identified in rat brain and named virodhamine (P ...

Cannabinoid Mechanisms of Pain Suppression 537 spinothalamic tract. FAAH is also found in Lissauer’s tract, which comprises pri- ...

538 J.M. Walker and A.G. Hohmann tivity but a reduced inflammatory response (edema) to carrageenan via a non- cannabinoid mechan ...

Cannabinoid Mechanisms of Pain Suppression 539 type mice, in contrast to another study published the same year on a different CB ...

540 J.M. Walker and A.G. Hohmann some using smoked marijuana and some using∆^9 -THC by the oral or intravenous routes. Some stud ...

Cannabinoid Mechanisms of Pain Suppression 541 which undoubtedly induced tolerance in the subjects. This confound is so deeply e ...

542 J.M. Walker and A.G. Hohmann 6.2 Clinical Pain The studies discussed in this section are the most compelling because the sub ...

Cannabinoid Mechanisms of Pain Suppression 543 man immunodeficiency virus (HIV) RNA levels, CD4+and CD8+cell counts, or protease ...

544 J.M. Walker and A.G. Hohmann Adams IB, Compton DR, Martin BR (1998) Assessment of anandamide interaction with the cannabinoi ...

Cannabinoid Mechanisms of Pain Suppression 545 Bridges D, Rice AS, Egertová M, Elphick MR, Winter J, Michael GJ (2003) Localisat ...