Cannabinoids

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Handbook of Experimental Pharmacology Volume 168 Editor-in-Chief K. Starke, Freiburg i. Br. Editorial Board G.V.R. Born, London ...

Cannabinoids Contributors M.E.Abood,S.Bátkai,T.Bisogno,G.A.Cabral,M.J.Christie, A.A. Coutts, S.N. Davies, R. de Miguel, L. De Pe ...

Professor Dr. Roger Pertwee School of Medical Sciences Institute of Medical Science University of Aberdeen Foresterhill Aberdeen ...

In memory of H.J.C. and Bill Paton and for Teresa. http://www.allitebooks.com ...

Preface Less than 20 years ago the field of cannabis and the cannabinoids was still con- sidered a minor, somewhat quaint, area ...

VIII Preface At cannabinoid meetings in the past, very few representatives of the pharmaceu- tical companies were present. Now t ...

List of Contributors ...

List of Contents PharmacologicalActionsofCannabinoids .................. 1 R.G. Pertwee Cannabinoid Receptor Signaling.......... ...

XII List of Contents Retrograde Signalling by Endocannabinoids................. 367 C.W. Vaughan, M.J. Christie EffectsontheImmu ...

Pharmacological Actions of Cannabinoids R.G. Pertwee School of Medical Sciences, Institute of Medical Sciences, University of Ab ...

2 R.G. Pertwee are found mainly on immune cells, one of their roles being to modulate cytokine release. Endogenous ligands for t ...

Pharmacological Actions of Cannabinoids 3 Fig. 1.The structures of four plant cannabinoids,∆^9 -THC,∆^8 -THC, cannabinol and can ...

4 R.G. Pertwee mediated. In experiments with NG108-15 cells, Sugiura et al. (1996) found CB 1 - mediated increases in intracellu ...

Pharmacological Actions of Cannabinoids 5 Fig. 3.The structures of five putative endogenous cannabinoids cium released from inos ...

6 R.G. Pertwee (reviewed in the chapter by Vaughan and Christie, this volume). There is also evi- dence that following their rel ...

Pharmacological Actions of Cannabinoids 7 Table 1.Typical dissociation constant (KD) values of radiolabelled ligands at cannabin ...

8 R.G. Pertwee Table 2.Examples ofKivalues of certain cannabinoid CB 1 and/or CB 2 receptor agonists for the in vitro displaceme ...

Pharmacological Actions of Cannabinoids 9 Table 2.(continued) Agonist CB 1 CB 2 Reference Kivalue (nM) Kivalue (nM) 1.89 0.28 Sh ...

10 R.G. Pertwee Table 3.Kivalues of cannabinoid receptor antagonists/inverse agonists for the in vitro displacement of [^3 H]CP5 ...