Cannabinoids

334 B. Szabo and E. Schlicker

Table 1.

(continued

)

Neurotransmitter Species

Region

Method

Mechanism of presynaptic inhibition

Reference(s)

Glutamate

Rat

Hippocampus(cell culture)

Electrophysiology (patch clamp) Vesicle release machinery inhibited

Ca

2+

channels involved

Sullivan 1999

Glutamate

Rat

Hippocampus(cell culture)

Electrophysiology(patchclamp),microfluorometry(Ca

2+

spikes determined)

The inhibition is pertussis toxin sensitive Shen et al. 1996,

Shen and Thayer 1999,Kouznetsova et al. 2002

Glutamate?GABA?

Rat

Hippocampus(cell culture)

Release of the vesicle markerFM1–43

No details given

Kim and Thayer 2000

Glutamate

Rat

Hippocampus(synaptosomes)

Endogenous glutamatechemically determined(4-AP evoked release)

The inhibition is pertussis toxin sensitiveCa

2+

channels involved

Vesicle release machinery not inhibitedPKA not involved

Wang 2003

Glutamate

Mouse, rat Hippocampus

(brain slice)

Electrophysiology (patch clamp) No CB

receptors are involved 1

Hájos et al. 2001;Hájos and Freund 2002

Glutamate

Rat, mouse Hippocampus

(synaptosomes)

(^3) [
H]Glutamate release
No CB
receptors are involved 1
Köfalvi et al. 2003
Glutamate
Mouse
Hippocampus(brain slice)
Electrophysiology (patch clamp) The inhibition is pertussis toxin sensitiv
e
Vesicle release machinery inhibited
Misner and Sullivan 1999
Glutamate
Mouse
Amygdala
Electrophysiology
(patch clamp,
extracell. recording)
The inhibition is pertussis toxin sensitiveVesicle release machinery inhibited+K
channels involved
Ca
2+
channels not involved
Azad et al. 2003
Glutamate
Rat
Cerebellum(brain slice)
Electrophysiology (patch clamp) Vesicle release machinery inhibited
+K
channels involved
Ca
2+
channels only indirectly involved
Levenes et al. 1998, Danieland Crepel 2001
Glutamate
Rat
Cerebellum(brain slice)
Electrophysiology (patch clamp) Vesicle release machinery not inhibited
Takahashi and Linden 2000