Cannabinoids

Effects of Cannabinoids on Neurotransmission 339

Table 2.

(continued

)

Neurotransmitter Species

Region

Method

Mechanism of presynaptic inhibition

Reference(s)

GABA

Rat

Hippocampus(brain slice)

Electrophysiology (patch clamp) No details given

Hoffman et al. 2003b

GABA

Rat

Hippocampus(brain slice)

Electrophysiology (patch clamp) Vesicle release machinery inhibited

Wilson and Nicoll 2001

GABA

Rat

Hippocampus(cell culture)

Electrophysiology (patch clamp) Vesicle release machinery inhibited

Irving

et al. 2000

GABA

Rat

Hippocampus(cell culture)

Electrophysiology (patch clamp) No details given

Ohno-Shosaku et al. 2001

GABA

Rat

Hippocampus(brain slice)

(^3) [
H]GABA release
No details given
Katona et al. 1999
GABA
Mouse
Hippocampus(brain slice)
Electrophysiology (patch clamp) No details given
Hájos et al. 2001
GABA
Man
Hippocampus(brain slice)
(^3) [
H]GABA release
No details given
Katona et al. 2000
GABA
Man
Hippocampus(brain slice)
Electrophysiology (patch clamp) Vesicle release machinery not inhibited
Nakatsuka et al. 2003
GABA
Rat, mouse Amygdala
(brain slice)
Electrophysiology (patch clamp) Vesicle release machinery not inhibited
Kat
ona et al. 2001
GABA
Mouse
Amygdala(brain slice)
Electrophysiology (patch clamp) Vesicle release machinery inhibited
Azad et al. 2003
GABA
Rat
Periaqueductal grey(brain slice)
Electrophysiology (patch clamp) Vesicle release machinery inhibited
Vaughan
et al. 2000
GABA
Rat
Rostral ventro-medial medullaoblongata(brain slice)
Electrophysiology (patch clamp) Vesicle release machinery inhibited
Vaughan et al. 1999
GABA
Rat
Cerebellum(brain slice)
Electrophysiology (patch clamp) IntracellularCa
2+
concentrationdecreased Kreitzer and Regehr 2001