“9.61x6.69” b2815 Tissue Engineering and Nanotheranostics
Magnetic Nanohybrids for Magnetic Resonance Imaging 139
at the tumor site for 5 min at 10 min post injection. There was very
minute differences observed in the tumor growth when they used
NSs and NIR separately. However, Mau–NSs+NIR produced
significant heat to kill the tumor (Fig. 25(d)). Moreover, mice with
various treatment groups maintained their body weights throughout
the experimental time period which confirmed that NSs are unable to
generate toxicity to the mice as shown in Fig. 25(e). This study sug-
gested that MAu–NSs have the ability to ablate and stop the tumor
regrowth.
4. Conclusion and Prospective
Magnetic hybrid nanoparticles can be considered as the most prob-
lematic or complex colloidal particles in existence. In this chapter, we
have highlighted the most recent strategies focused on the complex
design, synthesis and theranostic applications of these multifunctional
magnetic nanohybrids materials. MRI contrast probes integrated with
therapeutic agents have demonstrated excellent ability in MR signal
enhancement and also the capability for tumor cell ablation via reac-
tive oxygen species (ROS). These combined features of magnetic
hybrid compounds present a novel platform for multifunctional pur-
poses such as diagnosis and therapeutic functions. At present, most
researches focused on the fabrication part, but the applications are
still in infancy. Although some MNHPs have revealed excellent tools
for extensive applications, a number of challenges have to be investi-
gated deeply. Therefore, the following characteristics might need bet-
ter concentration in the future. In the fabrication part, the interface
between two compounds and their morphology have not been con-
trolled very well to provide stability. Therefore, this issue still needs
to be addressed by developing new synthesis techniques or improving
the existing ones. Moreover, demand for non-toxic novel MRI con-
trast agents with ultrasensitive imaging and advanced functionality is
very high. Magnemite or magnetite particles may impose additional
danger because the pH in the endolysosomes is low. The acidic envi-
ronment produced by ferric ions can destroy many biochemical pro-
cesses which are very critical to the process. Some stable coating may
