Personalized_Medicine_A_New_Medical_and_Social_Challenge
The characteristics of the host are extremely important when starting treatment as pharmacogenomic properties determine the leve ...
preventive colectomy in patients at high risk for developing colorectal cancer.^12 Genetic determinants of other gastrointestina ...
interplay of genotype and phenotype of the host and the bacteria respectively. The phenotype of the host is primarily expressed ...
the large variety of disease manifestations, it is up to the personalized approach to try and find the best solution for the pat ...
References Barrett JC, Hansoul S, Nicolae DL et al (2008) Genome-wide association defines more than 30 distinct susceptibility l ...
Ramchandani R, Wang Y, Booth BP et al (2007) The role of SN-38 exposure UGT1A1*28 polymorphism, and baseline bilirubin level in ...
Personalized Medicine in Clinical Pharmacology Dinko Vitezic ́, Nada Božina, Jasenka Mršić-Pelčić, Viktorija ErdeljićTurk, and I ...
1 Introduction Clinical pharmacology could be defined as a translational discipline between basic pharmacology and applied pharm ...
and storage conditions, precision and accuracy of the analytical method, validity of pharmacokinetic models and assumptions, com ...
Examples of drugs suitable for therapeutic drug monitoring include (see footnote 4) the following:^7 digoxin (target range: 0.8 ...
3 Drug Therapy Individualization in Patients with Renal and Liver Dysfunction The liver and kidneys are the main organs involved ...
(MDRD) equation (four variables) has demonstrated excellent precision and accu- racy in the prediction of GFR. Since it provides ...
(CLD), different mechanisms are responsible for altered drug destiny in organism: reduction of portal blood flow that affects th ...
4 Personalized Medicine and Pharmacogenomics The recognition that a part of interindividual variability in drug response is inhe ...
(UGT1A1)N-Acetyltransferase 2 (NAT2), and glutathionS-transferase (GST) have been demonstrated to be of great importance for cli ...
Table 4 Guidelines and recommendations for drug dosing according to genotype Drug Gene Recommendation Guidelines by Abacavir HLA ...
Table 4 (continued) Drug Gene Recommendation Guidelines by containing regimens as compared to patients with unfavorable response ...
Table 4 (continued) Drug Gene Recommendation Guidelines by genotype del/del), ivacaftor is not recommended. See full guideline f ...
5 Conclusion In spite of limitations of this chapter, which do not cover all aspects or fields in which clinical pharmacology is ...
chronic kidney disease. A clinical update from kidney disease: improving global outcomes (KDIGO). Kidney Int 80(11):1122–1137 No ...
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