The DisGeNET database [30] is an integrated database of
human gene-disease associations from various expert-curated data-
bases including UniProt, Comparative Toxicogenomics Database,
ClinVar, Orphanet, NHGRI-EBI GWAS Catalog, etc. In current
version, it contains 429,036 associations, between 17,381 genes
and 15,093 diseases and phenotypes.2.2 lncRNA Database LNCipedia (http://www.lncipedia.org/)[31] is a comprehensive
database of human lncRNA database which contains 113,513
annotated human lncRNA transcripts by integrating different data-
bases. In addition, it provides tools to predict protein-coding
potential.
NONCODE (http://www.bioinfo.org/noncode/)[32]isan
integrated knowledgebase including almost all noncoding RNA. It
contains 16 species (human, mouse, cow, rat, chimpanzee, gorilla,
orangutan, rhesus macaque, opossum, platypus, chicken, zebra fish,
fruit fly, Caenorhabditis elegans, yeast, and Arabidopsis) and
527,336 lncRNA transcripts in the latest version.
LncRBase (http://bicresources.jcbose.ac.in/zhumur/lncrbase)
[33] is a repository of human and mouse lncRNA which contains
216,562 lncRNA transcript entries in total. In this database, it col-
lected basic lncRNA transcript features, genomic location, overlap-
ping small noncoding RNAs, associated Repeat Elements, associated
imprinted genes, and lncRNA promoter information.
lncRNAWiki (http://lncrna.big.ac.cn)[34] is a comprehensive
resource of human long noncoding RNAs knowledge. 105,255
non-redundant lncRNA transcripts are obtained by integrating
three databases: GENCODE, NONCODE, and LNCipedia. In
addition, based on lncRNA genomic location in respect to
protein-coding genes, lncRNAs are classified into seven groups
(intergenic, intronic (S), intronic (AS), overlapping (S), overlap-
ping (AS), sense, and antisense) in the database.
lncRNAdb (http://www.lncrnadb.org)[35] is a knowledge
resource which aims to provide comprehensive annotations of
eukaryotic long noncoding RNAs. In this database, every entry
contains sequence, structure, genomic context, gene expression,
subcellular localization, conservation, and function information of
lncRNA. Users can search and download lncRNA information and
submit new entries.
LncRNADisease (http://www.cuilab.cn/lncrnadisease)[36]is
a manually curated database of experimentally supported lncRNA-
disease associations. It includes more than 1000 lncRNA-disease
entries and 475 lncRNA interaction entries, including 321 lncRNAs
and 221 diseases from500 publications.
Lnc2Cancer (http://www.bio-bigdata.net/lnc2cancer)[37]is
a resource of cancer-related lncRNAs which contains 1488 entries
of associations between 666 human lncRNAs and 97 human can-
cers through review of more than 2000 published papers. It also
Identifying Interactions Between Long Noncoding RNAs and Diseases... 209