- In general, subgroup analysis could be done on any character-
istics of included studies to detect whether the study character-
istics could explain the heterogeneities.
References
- Koricheva J, Gurevitch J (2013) Place of meta-
analysis among other methods of research syn-
thesis. In: Koricheva J, Gurevitch J, Mengersen
K (eds) Handbook of meta-analysis in ecology
and evolution. Princeton University Press - Borenstein M, Hedges LV, Higgins JPT, Roth-
stein HR (2009) Introduction to meta-
analysis. John Wiley & Sons, Ltd., Chichester.
https://doi.org/10.1002/9780470743386 - Evangelou E, Ioannidis JPA (2013) Meta-
analysis methods for genome-wide association
studies and beyond. Nat Rev Genet
14:379–389. https://doi.org/10.1038/
nrg3472 - Levinson DF (2005) Meta-analysis in psychiatric
genetics. Curr Psychiatry Rep 7:143–151.
https://doi.org/10.1007/s11920-005-0012-9 - Borenstein M (2009) Effect sizes for continu-
ous data. In: Cooper H, Hedges LV, Valentine
JC (eds) The handbook of research synthesis
and meta-analysis. Russell Sage Foundation - Tseng GC, Ghosh D, Feingold E (2012) Com-
prehensive literature review and statistical con-
siderations for microarray meta-analysis.
Nucleic Acids Res 40:3785–3799. https://
doi.org/10.1093/nar/gkr1265 - Zhu H, Leung SW (2015) Identification of
microRNA biomarkers in type 2 diabetes: a
meta-analysis of controlled profiling studies.
Diabetologia 58:900–911. https://doi.org/
10.1007/s00125-015-3510-2 - Moher D, Liberati A, Tetzlaff J et al (2009)
Preferred reporting items for systematic
reviews and meta-analyses: the PRISMA state-
ment (reprinted from annals of internal medi-
cine). Phys Ther 89:873–880. https://doi.
org/10.1371/journal.pmed.1000097 - Minimum information about a microarray
experiment – MIAME. http://www.mged.
org/Workgroups/MIAME/miame_2.0.html - Kahn SE (2001) Clinical review 135: the
importance of beta-cell failure in the develop-
ment and progression of type 2 diabetes. J Clin
Endocrinol Metab 86:4047–4058 - Karolina DS, Armugam A, Sepramaniam S,
Jeyaseelan K (2012) MiRNAs and diabetes
mellitus. Expert Rev Endocrinol Metab
7:281–300. https://doi.org/10.1586/eem.
12.21 - Winer N, Sowers JR (2004) Epidemiology of
diabetes. J Clin Pharmacol 44:397–405.
https://doi.org/10.1177/
0091270004263017 - International Diabetes Federation (IDF)
(2015) IDF Diabetes Atlas, 7th edn.idf.org.
doi:https://doi.org/10.1289/image.ehp.
v119.i03 - Shantikumar S, Caporali A, Emanueli C (2012)
Role of microRNAs in diabetes and its cardio-
vascular complications. Cardiovasc Res
93:583–593. https://doi.org/10.1093/cvr/
cvr300 - Rodriguez A, Griffiths-Jones S, Ashurst JL,
Bradley A (2004) Identification of mammalian
microRNA host genes and transcription units.
Genome Res 14(10):1902.https://doi.org/
10.1101/gr.2722704 - Lee Y, Kim M, Han J et al (2004) MicroRNA
genes are transcribed by RNA polymerase
II. EMBO J 23:4051–4060.https://doi.org/
10.1038/sj.emboj.7600385 - He L, Hannon GJ (2004) MicroRNAs: small
RNAs with a big role in gene regulation. Nat
Rev Genet 5:522–531. https://doi.org/10.
1038/nrg1379 - Bartel DP (2004) MicroRNAs: genomics, bio-
genesis, mechanism, and function. Cell
116:281–297. https://doi.org/10.1016/
S0092-8674(04)00045-5 - Arroyo JD, Chevillet JR, Kroh EM et al (2011)
Argonaute2 complexes carry a population of
circulating microRNAs independent of vesicles
in human plasma. Proc Natl Acad Sci U S A
108:5003–5008. https://doi.org/10.1073/
pnas.1019055108 - Vickers KC, Palmisano BT, Shoucri BM et al
(2011) MicroRNAs are transported in plasma
and delivered to recipient cells by high-density
lipoproteins. Nat Cell Biol 13:423–433.
https://doi.org/10.1038/ncb2210 - Gibbings DJ, Ciaudo C, Erhardt M, Voinnet O
(2009) Multivesicular bodies associate with
components of miRNA effector complexes
and modulate miRNA activity. Nat Cell Biol
11:1143–1149. https://doi.org/10.1038/
ncb1929 - Sua ́rez Y, Sessa WC (2009) MicroRNAs as
novel regulators of angiogenesis. Circ Res
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