Extended Data Fig. 3 | Distribution of reticulocytes and RNA
concentrations across Dantu genotypes. Reticulocyte counts, and
concentrations of RNA extracted from reticulocytes, were compared across
Dantu genotypes. Reticulocyte count data were tested for 8 non-Dantu
individuals, 7 Dantu heterozygotes and 7 Dantu homozygotes, while RNA
concentrations were measured in 9 non-Dantu, 7 Dantu heterozygotes and
7 Dantu homozygotes. Medians are indicated by the middle red lines in the
boxplots, with the 25th and 75th percentiles indicated by the tops and bottoms
of each plot, and the total data ranges indicated by whiskers. Statistical
comparisons across the three genotype groups were performed by a one-way
ANOVA; pairwise comparisons between genotype groups were performed
using Tukey’s HSD test, correcting for multiple pairwise comparison tests
using Benjamini–Hochberg FDR. Significant differences were observed in
reticulocyte count (non-Dantu versus Dantu homozygote, P = 0.0023) and RNA
concentrations (non-Dantu versus Dantu homozygote, P = 0.0015; non-Dantu
versus Dantu heterozygote, P = 0.0088). *P < 0.05; **P < 0.01.