BNF for Children (BNFC) 2018-2019

TABLE 16

Drugs that increase serum potassium

The following is a list of some drugs that increase serum potassium concentrations (note that this list is not exhaustive). Concurrent use of
two or more drugs from this list might increase the risk of hyperkalaemia (hyperkalaemia is particularly notable when ACE inhibitors or
angiotensin-II receptor antagonists are given with spironolactone or eplerenone).

aceclofenac
acemetacin
aliskiren
amiloride
azilsartan
candesartan
captopril
celecoxib
ciclosporin
dalteparin
darbepoetin alfa
dexibuprofen

dexketoprofen

diclofenac

drospirenone

enalapril

enoxaparin

eplerenone

epoetin alfa

epoetin beta

epoetin zeta

eprosartan

etodolac

etoricoxib

fenoprofen

flurbiprofen

heparin (unfractionated)

ibuprofen

imidapril

indometacin

irbesartan

ketoprofen

ketorolac

lisinopril

losartan

mefenamic acid

meloxicam

nabumetone

naproxen

olmesartan

parecoxib

perindopril

piroxicam

potassium canrenoate

potassium chloride

quinapril

ramipril

spironolactone

sulindac

tacrolimus

telmisartan

tenoxicam

tiaprofenic acid

tinzaparin

tolfenamic acid

tolvaptan

trandolapril

triamterene

trimethoprim

valsartan

TABLE 17

Drugs that reduce serum potassium

The following is a list of some drugs that reduce serum potassium concentrations (note that this list is not exhaustive and that other drugs
can cause hypokalaemia in overdose). Concurrent use of two or more drugs from this list might increase the risk of hypokalaemia.
Hypokalaemia can increase the risk of torsade de pointes, which might be additive with the effects of drugs that prolong the QT interval
(see table of drugs that prolong the QT interval).

aminophylline
amphotericin
bambuterol
beclometasone
bendroflumethiazide
betamethasone
budesonide

bumetanide

chlorothiazide

chlortalidone

clopamide

cyclopenthiazide

deflazacort

dexamethasone

fludrocortisone

formoterol

furosemide

hydrochlorothiazide

hydrocortisone

hydroflumethiazide

indacaterol

indapamide

methylprednisolone

metolazone

olodaterol

prednisolone

prednisone

salbutamol

salmeterol

terbutaline

theophylline

torasemide

triamcinolone

vilanterol

xipamide

TABLE 18

Drugs that cause hyponatraemia

The following is a list of some drugs that reduce sodium concentrations (note that this list is not exhaustive). Concurrent use of two or
more drugs from this list might increase the risk of hyponatraemia.

aceclofenac
acemetacin
amiloride
amitriptyline
bendroflumethiazide
bumetanide
carbamazepine
celecoxib
chlorothiazide
chlortalidone
citalopram
clomipramine

clopamide

cyclopenthiazide

dapoxetine

desmopressin

dexibuprofen

dexketoprofen

diclofenac

dosulepin

doxepin

duloxetine

eplerenone

escitalopram

etodolac

etoricoxib

fenoprofen

fluoxetine

flurbiprofen

fluvoxamine

furosemide

hydrochlorothiazide

hydroflumethiazide

ibuprofen

imipramine

indapamide

indometacin

ketoprofen

ketorolac

mefenamic acid

meloxicam

metolazone

nabumetone

naproxen

nortriptyline

parecoxib

paroxetine

piroxicam

sertraline

sodium picosulfate

spironolactone

sulindac

tenoxicam

tiaprofenic acid

tolfenamic acid

torasemide

triamterene

trimethoprim

trimipramine

xipamide

TABLE 19

Drugs that cause ototoxicity

The following is a list of some drugs that cause ototoxicity (note that this list is not exhaustive). Concurrent use of two or more drugs from
the list might increase this risk.

amikacin
bumetanide
capreomycin
carboplatin

cisplatin

furosemide

gentamicin

neomycin

oxaliplatin

streptomycin

telavancin

tobramycin

torasemide

vancomycin

vinblastine

vincristine

vindesine

vinflunine

vinorelbine

TABLE 20

Drugs with neuromuscular blocking effects

The following is a list of some drugs with neuromuscular blocking effects (note that this list is not exhaustive). Concurrent use of two or
more drugs from the list might increase this risk.

amikacin
atracurium
botulinum toxin type A
botulinum toxin type B

cisatracurium

colistimethate

gentamicin

mivacurium

neomycin

neostigmine

pancuronium

polymyxins

pyridostigmine

rocuronium

streptomycin

suxamethonium

tobramycin

vecuronium

BNFC 2018 – 2019 Appendix 1 Interactions 851

Interactions

|Appendix 1

A1