▶Amiodaroneis predicted to slightly increase the concentration
ofantiepileptics(fosphenytoin, phenytoin). Monitor and adjust
dose.rStudy→Also seeTABLE 12p. 850
▶Antifungals, azoles(fluconazole)are predicted to increase the
exposure todronedarone.rTheoretical→Also seeTABLE 9
p. 849
▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure topropafenone.
Monitor and adjust dose.oStudy
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the exposure todisopyramide. Avoid.
rTheoretical→Also seeTABLE 9p. 849
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)
very markedly increase the exposure todronedarone. Avoid.
rStudy→Also seeTABLE 9p. 849
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the exposure topropafenone. Monitor
and adjust dose.rStudy
▶Antifungals, azoles(miconazole)are predicted to increase the
exposure todisopyramide. Use with caution and adjust dose.
rTheoretical
▶Antifungals, azoles(posaconazole)are predicted to increase the
exposure toantiarrhythmics(disopyramide, dronedarone).
Avoid.rTheoretical
▶Dronedaroneis predicted to increase the exposure to
antihistamines, non-sedating(fexofenadine, mizolastine).r
Theoretical
▶Dronedaroneis predicted to increase the exposure to
antihistamines, non-sedating(rupatadine). Avoid.oStudy
▶Dronedaroneis predicted to increase the concentration of
antimalarials(piperaquine).rTheoretical
▶Dronedaroneis predicted to increase the exposure to
apixaban.oTheoretical
▶Aprepitantincreases the exposure todronedarone.r
Theoretical
▶Aprepitantis predicted to increase the exposure to
propafenone. Monitor and adjust dose.oStudy
▶Dronedaroneis predicted to increase the exposure toaxitinib.
oTheoretical
▶Dronedaroneis predicted to increase the exposure to
bedaquiline. Avoid prolonged use.nTheoretical→Also see
TABLE 9p. 849
▶Antiarrhythmics(amiodarone, disopyramide, dronedarone,
flecainide, lidocaine)are predicted to increase the risk of
cardiovascular side-effects when given withbeta blockers,
non-selective. Use with caution or avoid.rStudy→Also see
TABLE 6p. 848→Also seeTABLE 9p. 849
▶Propafenoneis predicted to increase the risk of cardiovascular
side-effects when given withbeta blockers, non-selective
(labetalol, levobunolol, nadolol, oxprenolol, pindolol, sotalol).
Use with caution or avoid.rStudy
▶Propafenoneincreases the risk of cardiovascular side-effects
when given withbeta blockers, non-selective(propranolol). Use
with caution or avoid.rStudy
▶Propafenoneis predicted to increase the exposure tobeta
blockers, non-selective(timolol)andbeta blockers, non-selective
(timolol)are predicted to increase the risk of cardiodepression
when given withpropafenone.rAnecdotal
▶Antiarrhythmics(amiodarone, disopyramide, dronedarone,
flecainide, lidocaine)are predicted to increase the risk of
cardiovascular side-effects when given withbeta blockers,
selective. Use with caution or avoid.rStudy→Also see
TABLE 6p. 848
▶Propafenoneis predicted to increase the risk of cardiovascular
side-effects when given withbeta blockers, selective
(acebutolol, atenolol, betaxolol, bisoprolol, celiprolol, esmolol).
Use with caution or avoid.rStudy
▶Propafenoneis predicted to increase the exposure tobeta
blockers, selective(metoprolol).oStudy
▶Propafenoneis predicted to increase the exposure tobeta
blockers, selective(nebivolol)andbeta blockers, selective
(nebivolol)are predicted to increase the risk of
cardiodepression when given withpropafenone. Avoid.r
Theoretical
▶Bosentanis predicted to decrease the exposure to
dronedarone.rTheoretical
▶Dronedaroneis predicted to increase the exposure to
bosutinib. Avoid or adjust dose.rTheoretical→Also see
TABLE 9p. 849
▶Dronedaroneis predicted to increase the exposure to
buspirone. Use with caution and adjust dose.oStudy
▶Dronedaroneis predicted to increase the exposure to
cabozantinib.oTheoretical→Also seeTABLE 9p. 849
▶Caffeine citratedecreases the efficacy ofadenosine. Separate
administration by 24 hours.nStudy
▶Calcium channel blockers(diltiazem, verapamil)increase the
exposure todronedaroneanddronedaroneincreases the
exposure tocalcium channel blockers(diltiazem, verapamil).
oStudy
▶Calcium channel blockers(diltiazem, verapamil)are predicted to
increase the exposure topropafenone. Monitor and adjust
dose.oStudy
▶Calcium channel blockers(verapamil)increase the risk of
cardiodepression when given withflecainide.r
Anecdotal→Also seeTABLE 6p. 848
▶Dronedaroneis predicted to increase the exposure tocalcium
channel blockers(amlodipine, felodipine, lacidipine,
lercanidipine, nicardipine, nifedipine, nimodipine). Monitor and
adjust dose.oStudy
▶Amiodaroneis predicted to increase the risk of
cardiodepression when given withcalcium channel blockers
(diltiazem, verapamil). Avoid.rTheoretical→Also see
TABLE 6p. 848
▶Disopyramideis predicted to increase the risk of
cardiodepression when given withcalcium channel blockers
(verapamil).rTheoretical
▶Antiarrhythmics(amiodarone, dronedarone)are predicted to
increase the exposure toceritinib.oTheoretical→Also
seeTABLE 9p. 849
▶Amiodaroneincreases the concentration ofciclosporin.
Monitor concentration and adjust dose.rStudy
▶Dronedaroneincreases the concentration ofciclosporin.r
Study
▶Ciclosporinincreases the exposure todronedarone. Avoid.
rTheoretical
▶Cobicistatvery markedly increases the exposure to
dronedarone. Avoid.rStudy
▶Cobicistatis predicted to increase the exposure to
propafenone. Monitor and adjust dose.rStudy
▶Dronedaroneis predicted to increase the exposure to
cobimetinib.rTheoretical
▶Dronedaroneis predicted to increase the exposure to
colchicine. Adjustcolchicinedose with moderate inhibitors of
CYP3A4.rStudy
▶Dronedaroneis predicted to increase the exposure to
corticosteroids(methylprednisolone). Monitor and adjust dose.
oStudy
▶Amiodaroneincreases the anticoagulant effect ofcoumarins.
rStudy
▶Propafenoneincreases the anticoagulant effect ofcoumarins.
Monitor INR and adjust dose.oStudy
▶Crizotinibis predicted to increase the exposure to
propafenone. Monitor and adjust dose.oStudy
▶Amiodaroneincreases the exposure todabigatran. Adjust
dabigatrandose.oStudy
▶Dronedaroneslightly increases the exposure todabigatran.
Avoid.rStudy
▶Daclatasviris predicted to increase the risk of severe
bradycardia or heart block when given withamiodarone. Refer
to specialist literature.rAnecdotal
▶Dronedaroneis predicted to slightly increase the exposure to
darifenacin.oStudy
▶Darifenacinis predicted to increase the concentration of
flecainide.oTheoretical
▶Dronedaroneis predicted to increase the exposure to
dasatinib.rStudy→Also seeTABLE 9p. 849
▶Antiarrhythmics(amiodarone, dronedarone)are predicted to
moderately increase the exposure todigoxin. Monitor and
adjustdigoxindose,p. 81.rStudy→Also seeTABLE 6p. 848BNFC 2018 – 2019 Antiarrhythmics—Antiarrhythmics 859
Interactions|Appendix 1A1