Live vaccines(continued)
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
dactinomycin. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given withdimethyl
fumarate. Public Health England advises avoid (refer to Green
Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
etanercept. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
etoposide. Public Health England advises avoid (refer to Green
Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
everolimus. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
fingolimod. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
fludarabine. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
fluorouracil. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
gemcitabine. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
hydroxycarbamide. Public Health England advises avoid (refer
to Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
irinotecan. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given withiron
chelators(dexrazoxane). Avoid.rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
leflunomide. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
mercaptopurine(high-dose). Public Health England advises
avoid (refer to Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
methotrexate(high-dose). Public Health England advises
avoid (refer to Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
mitomycin. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
monoclonal antibodies. Public Health England advises avoid
(refer to Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
mycophenolate. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given withpemetrexed. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given withplatinum
compounds. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
procarbazine. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
raltitrexed. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
sirolimus. Public Health England advises avoid (refer to Green
Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
tacrolimus. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given withtaxanes
(docetaxel, paclitaxel). Public Health England advises avoid
(refer to Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given withtegafur.
Public Health England advises avoid (refer to Green Book).
rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
temsirolimus. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
teriflunomide. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
tioguanine. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinespotentially increase the risk of generalised
infection (possibly life-threatening) when given with
tofacitinib. Avoid.rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
topotecan. Public Health England advises avoid (refer to Green
Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
trabectedin. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Venetoclaxpotentially decreases the efficacy oflive vaccines.
Avoid.rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given withvinca
alkaloids. Public Health England advises avoid (refer to Green
Book).rTheoretical
Lixisenatide→seeTABLE 14p. 850 (antidiabetic drugs)
SEPARATION OF ADMINISTRATIONSome orally administered
drugs should be taken at least 1 hour before, or 4 hours after,
lixisenatide injection.
Lofepramine→see tricyclic antidepressants
Lofexidine→seeTABLE 8p. 848 (hypotension),TABLE 9p. 849 (QT-
interval prolongation),TABLE 11p. 849 (CNS depressant effects)
Lomitapide→seeTABLE 1p. 847 (hepatotoxicity)
FOOD AND LIFESTYLEBitter (Seville) orange is predicted to
increase the exposure to lomitapide; separate administration
by 12 hours.
▶Alprazolamis predicted to increase the exposure tolomitapide.
Separate administration by 12 hours.oTheoretical944 Live vaccines—Lomitapide BNFC 2018 – 2019
Interactions|Appendix 1A1