Avoid and for 1 week after stoppingsafinamide.r
Theoretical→Also seeTABLE 13p. 850
▶Reboxetineis predicted to increase the risk of a hypertensive
crisis when given withlinezolid. Avoid.rTheoretical
▶Rifampicinslightly decreases the exposure tolinezolid.
oStudy
▶Sympathomimetics, inotropicare predicted to increase the risk
of elevated blood pressure when given withlinezolid. Avoid.
rTheoretical
▶Sympathomimetics, vasoconstrictor(adrenaline/epinephrine,
ephedrine, isometheptene, noradrenaline/norepinephrine,
phenylephrine)are predicted to increase the risk of elevated
blood pressure when given withlinezolid. Avoid.r
Theoretical
▶Sympathomimetics, vasoconstrictor(pseudoephedrine)increase
the risk of elevated blood pressure when given withlinezolid.
Avoid.rStudy
Liothyronine→see thyroid hormones
Liraglutide→seeTABLE 14p. 850 (antidiabetic drugs)
Lisdexamfetamine→see amfetamines
Lisinopril→see ACE inhibitors
Lithium→seeTABLE 13p. 850 (serotonin syndrome),TABLE 9p. 849 (QT-
interval prolongation)
▶ACE inhibitorsare predicted to increase the concentration of
lithium. Monitor and adjust dose.rAnecdotal
▶Acetazolamidealters the concentration oflithium.r
Anecdotal
▶Aldosterone antagonists(eplerenone)potentially increase the
concentration oflithium. Avoid.oTheoretical
▶Aldosterone antagonists(spironolactone)potentially increase
the concentration oflithium.oStudy
▶Aminophyllineis predicted to decrease the concentration of
lithium.oTheoretical
▶Angiotensin-II receptor antagonistspotentially increase the
concentration oflithium. Monitor concentration and adjust
dose.rAnecdotal
▶Antiepileptics(carbamazepine, oxcarbazepine)are predicted to
increase the risk of neurotoxicity when given withlithium.
rAnecdotal
▶Calcitonin (salmon)decreases the concentration oflithium.
Monitor concentration and adjust dose.oStudy
▶Calcium channel blockers(diltiazem, verapamil)are predicted to
increase the risk of neurotoxicity when given withlithium.
rAnecdotal
▶Loop diureticsincrease the concentration oflithium. Monitor
and adjust dose.rStudy
▶Methyldopaincreases the risk of neurotoxicity when given
withlithium.rAnecdotal
▶NSAIDsincrease the concentration oflithium. Monitor and
adjust dose.rStudy
▶Phenothiazinespotentially increase the risk of neurotoxicity
when given withlithium.rAnecdotal→Also seeTABLE 9
p. 849
▶Potassium-sparing diuretics(triamterene)potentially increase
the clearance oflithium.oStudy
▶Quetiapinepotentially increases the risk of neurotoxicity
when given withlithium.rAnecdotal
▶Risperidonepotentially increases the risk of neurotoxicity
when given withlithium.rAnecdotal→Also seeTABLE 9
p. 849
▶Sodium bicarbonatedecreases the concentration oflithium.
rAnecdotal
▶Sulpiridepotentially increases the risk of neurotoxicity when
given withlithium.rAnecdotal→Also seeTABLE 9p. 849
▶Theophyllineis predicted to decrease the concentration of
lithium. Monitor concentration and adjust dose.o
Anecdotal
▶Thiazide diureticsincrease the concentration oflithium. Avoid
or adjust dose and monitor concentration.rStudy
▶Tricyclic antidepressantspotentially increase the risk of
neurotoxicity when given withlithium.rAnecdotal→Also
seeTABLE 13p. 850→Also seeTABLE 9p. 849
▶Zuclopenthixolpotentially increases the risk of neurotoxicity
when given withlithium.rAnecdotal→Also seeTABLE 9
p. 849
Live vaccines
Bacillus Calmette-Guérin vaccine.influenza vaccine (live).measles,
mumps and rubella vaccine, live.rotavirus vaccine.typhoid
vaccine, oral.varicella-zoster vaccine.yellow fever vaccine, live..GENERAL INFORMATIONOral typhoid vaccineis inactivated by
concurrent administration of antibacterials or
antimalarials: antibacterials should be avoided for 3 days
before and after oral typhoid vaccination;mefloquineshould
be avoided for at least 12 hours before or after oral typhoid
vaccination; for other antimalarials oral typhoid vaccine
vaccination should be completed at least 3 days before the
first dose of the antimalarial (except proguanil hydrochloride
with atovaquone, which can be given concurrently).
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
abatacept. Public Health England advises avoid (refer to Green
Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
alkylating agents. Public Health England advises avoid (refer
to Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
amsacrine. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
anakinra. Public Health England advises avoid (refer to Green
Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
anthracyclines. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
azathioprine(high-dose). Public Health England advises avoid
(refer to Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
baricitinib. Avoid.rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
belatacept. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
bleomycin. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
capecitabine. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
ciclosporin. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
cladribine. Public Health England advises avoid (refer to Green
Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
clofarabine. Public Health England advises avoid (refer to
Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
corticosteroids(high-dose). Public Health England advises
avoid (refer to Green Book).rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
cytarabine. Public Health England advises avoid (refer to
Green Book).rTheoreticalBNFC 2018 – 2019 Linezolid—Live vaccines 943
Interactions|Appendix 1A1