ImmunologicalTestMethods 135
Table2. 13 ImportantCDAntigens
Designation
(alternatives)
Cellswhichexpressthe
antigen
Functions
CD1 Corticalthymocytes,
Langerhanscells,dendritic
cells,Bcells,intestinal
epithelium
MHCclassI-likemolecule,asso-
ciatedwithb 2 microglobulin.
Possiblespecialsignificancein
specializedantigenpresentation
CD2(LFA-2) Tcells,thymocytes,natural
killercells
Adhesionmoleculewhichbinds
toCD58(LFA-3)andcanactivate
Tcells(LFA=lymphocytefunc-
tionantigen)
CD3 Thymocytes,Tcells Associatedwiththeantigen
receptorofTcells,andisneces-
saryforT-cellreceptorsurface
expressionandsignaltransduc-
tion
CD4 Severalgroupsofthymocytes,
Thelpercells,andinflamma-
toryTcells(abouttwo-thirds
oftheperipheralTcells),
monocytes,macrophages
Co-receptorforMHCclassII
molecules.Bindssignaltrans-
ducersviacytoplasmicportion.
Receptorforgp1 20 inHIV-1
andHIV-2
CD5 Thymocytes,Tcells,
asubgroupofBcells
BindstoCD72
CD8 Severalgroupsofthymocytes,
cytotoxicTcells(aboutone-
thirdoftheperipheralTcells)
Co-receptorforMHCclassI
molecules,bindssignaltrans-
ducerviacytoplasmicportion
CD1 0 BandTprecursorcells,bone
marrowstromacells
Zincmetalproteinase,andmar-
kerforacutelymphoidleukemia
ofpre-Bcells
CD11a(achain) Lymphocytes,granulocytes,
monocytes,andmacrophages
asubunitofb 2 integrinLFA-1
(associatedwithCD18).Bindsto
CD54(ICAM-1),CD1 02 (ICAM-2),
andICAM-3(CD50)
CD1 9 Bcells FormsacomplexwithCD2 1
(CR2)andCD8 1 (TAPA-1),
Co-receptorforBcells
2
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Kayser, Medical Microbiology © 2005 Thieme
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