Medical Microbiology

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ImmunologicalTestMethods 135

Table2. 13 ImportantCDAntigens


Designation
(alternatives)


Cellswhichexpressthe
antigen

Functions

CD1 Corticalthymocytes,
Langerhanscells,dendritic
cells,Bcells,intestinal
epithelium


MHCclassI-likemolecule,asso-
ciatedwithb 2 microglobulin.
Possiblespecialsignificancein
specializedantigenpresentation

CD2(LFA-2) Tcells,thymocytes,natural
killercells


Adhesionmoleculewhichbinds
toCD58(LFA-3)andcanactivate
Tcells(LFA=lymphocytefunc-
tionantigen)

CD3 Thymocytes,Tcells Associatedwiththeantigen
receptorofTcells,andisneces-
saryforT-cellreceptorsurface
expressionandsignaltransduc-
tion


CD4 Severalgroupsofthymocytes,
Thelpercells,andinflamma-
toryTcells(abouttwo-thirds
oftheperipheralTcells),
monocytes,macrophages


Co-receptorforMHCclassII
molecules.Bindssignaltrans-
ducersviacytoplasmicportion.
Receptorforgp1 20 inHIV-1
andHIV-2

CD5 Thymocytes,Tcells,
asubgroupofBcells


BindstoCD72

CD8 Severalgroupsofthymocytes,
cytotoxicTcells(aboutone-
thirdoftheperipheralTcells)


Co-receptorforMHCclassI
molecules,bindssignaltrans-
ducerviacytoplasmicportion

CD1 0 BandTprecursorcells,bone
marrowstromacells


Zincmetalproteinase,andmar-
kerforacutelymphoidleukemia
ofpre-Bcells

CD11a(achain) Lymphocytes,granulocytes,
monocytes,andmacrophages


asubunitofb 2 integrinLFA-1
(associatedwithCD18).Bindsto
CD54(ICAM-1),CD1 02 (ICAM-2),
andICAM-3(CD50)

CD1 9 Bcells FormsacomplexwithCD2 1
(CR2)andCD8 1 (TAPA-1),
Co-receptorforBcells


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