Medical Microbiology

ImmunologicalTestMethods 137

Table2. 13 Continued:ImportantCDAntigens

Designation
(alternatives)

Cellswhichexpressthe

antigen

Functions

CD40 Bcells,monocytes,dendritic
cells

Receptorforthecostimulatory

signalforBcells;bindsCD40

ligand(CD40-L)

CD40L ActivatedCD4Tcells LigandforCD40

CD4 4 (Pgp-1) Leukocytes,erythrocytes Bindshyaluronicacidand
mediatesadhesionofleukocytes

CD45,RO,RA,
RB(leukocyte
commonantigen,
LCA),T200,B220

Leukocytes Atyrosinephosphatasewhich

enhancessignalmediationvia

theantigenreceptorsofBand

Tcells;alternativesplicingresults

inmanyisoforms(seebelow)

CD54 Hematopoieticand
nonhematopoieticcells

Intercellularadhesionmolecule

(ICAM-1);bindstheCD11a/CD1 8

integrin(LFA-1)andtheCD11b/

CD1 8 integrin(MAC-1);receptor

forrhinoviruses

CD55(DAF) Hematopoieticand
nonhematopoieticcells

Decayacceleratingfactor(DAF);

bindsC3bandcleavesC3/C5

convertase

CD62E(ELAM-1,
E-selectin)

Endothelium Endothelialleukocyteadhesion

molecule(ELAM);bindssialyl-

Lewisxandmediatesrollingof

neutrophiliccellsalongendothe-

lium

CD64(FccRI) Monocytes,macrophages High-affinityreceptorforIgG

CD80(B7.1)
CD86(B7.2)

SubgroupofBcells Costimulatorswhichactas

ligandsforCD28andCTLA-4

CD88 Polymorphonuclearleukocytes,
macrophages,mastcells

Receptorforthecomplement

componentC5a

CD89 Monocytes,macrophages,
granulocytes,neutrophilscells,
subgroupsofBandTcells

IgAreceptor?

CD95
(APO-1,Fas)

Manydifferentcelllines;

uncleardistributioninvivo

BindsTNF-likeFasligands;

inducesapoptosis

2

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Kayser, Medical Microbiology © 2005 Thieme

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