Medicinal Chemistry

THIND mnemonic, 186, 187
thio ether metabolism, 152
thiocyanate, 362
thiopental, 278
thiophenes, 152
thioridazine, 14, 136
thiotepa, 449, 450
THIP, 273
thromboxanes, 473, 519, 520–527
thrombus, 523
thymidylate synthase as a target, 496–497
thymine nucleotide, 470
thymoleptic drugs, 498
thymus, 388
thyroglobulin, 360
thyroid, 311
peptide hormones of, 359–364
thyroid agonists and antagonists, 362–363
thyroid deficiency, 361
thyroid follicles, 362
thyroid stimulating hormone, 341, 346, 359
thyroidectomy, 362
thyrolibrin, 340, 341–342, 359
thyrotropin, 341, 346, 359
thyrotropin releasing hormone, 341–342
thyroxine, 18, 311, 360
thyroxine binding globulin, 360
thyroxine binding prealbumin, 360
TIA, 379
tiagabine, 273
tiludronate, 536
tinea capitis, 582
tinea corporis, 582
tissue plasminogen activator, 287
tobramycin, 574
tocainide, 155, 421
tocopherol, 511
tolazamide, 367
tolbutamide, 14, 18, 155, 367
tolcapone, 249
tolerance, receptor, 77
tolfenamic acid, 523
tolmetin, 525
tolrestat, 370
tolterodine, 213
tolycaine, 156
topiramate, 279, 422
Topliss decision tree, 143
topoisomerase enzyme, 452, 453, 581
topological descriptors, 53, 143
topotecan, 452
total parenteral nutrition, 532
toxicity testing, 159, 162
toxicology, 593
toxicophore, 8, 19

TPA, 287

TPN, 532

trabecular bone, 536

trandolapril, 375

tranquilizer, 276

trans fats, 472

trans-phenyl-cyclopropylamine, 498

transcription, DNA, 441, 453, 471

transesterification, 179

transfer RNA, 471

transferases, 468

transient ischemic attacks, 379

transition-state analogues, 485

translation, RNA, 441, 453, 471

transmembrane proteins, 412

tranylcypromine, 498

trephining, 108

tretinoin, 509

TRH, 341–342

triacylglycerols, 472

triamcinolone, 334

tricalcium phosphate, 537

tridemorph, 584

tridihexethylbromide, 214

triethylenemelamine, 449, 450

trifluoroalanine, 486

trifluridine, 552

triglycerides, 472

trimetaphan, 214

trimethoprim, 18, 579

tripeptide, 338

triptans, 260

trisaccharide, 475

tRNA, 471

troglitazone, 369

tropicamide, 213

TSH, 341, 346, 359

tuberculosis, 580

tubocurarine, 137, 215

tumor necrosis factor, 398, 401

tumorigenesis, 500

two-state receptor model, 87, 88

TXA 2 , 520, 522, 523

TXB 2 , 520

typhoid, 576

tyramine, 227, 498

UDCA, 316

ulcers, peptic, 267

uncompetitive inhibitors, 485

upregulation, receptor, 76

uracil nucleotide, 470

ursodeoxycholic acid, 316

useful drug concept, 159

uterine endometrium, 321

648 INDEX