Contraindications and Precautionsing cardiovascular disease • Hypertension • History of severe Contraindicated in:● Actioncytoma • Hepatic or renal insuffiNameTranylcy promine(Trade) Selegiline Generic results in an increase in the concentration of these endogenous rine, norepinephrine, dopamine, and serotonin. This action Inhibition of the enzyme monoamine oxidase, which is respon-sible for the decomposition of the biogenic amines, epineph-amines. (Emsam)system transdermal (Parnate) Half-life (hr)C/18–25 C/2.4–2.8 Pregnancy Category/metabolites)(including • Hypersensitivity • Pheochromo-●Indications●Unlabeled uses:●●●^ Depression Social anxiety Migraine disorderDepressionpreventionPanic disorder ciency • History of or exist-Not well Therapeutic Plasma Level Range Not well establishedestablishedAntidepressants Forms (mg) Available Transder mal Tabs: 109, 12 patches: 6, ●^437
2506_Ch26_417-446.indd 1437 2506 Ch 26 417 - 446 .indd Use Cautiously in:or frequent headaches • Concomitant use with other MAOIs, • Patients with diabetes mellitus • Patients with suicidal ide-ation • Agitated or hypomanic patients • Patients with a history of angina pectoris or hyperthyroidismAdverse Reactions and Side Effects● 1 ● bupropion, SSRIs, SARIs, buspirone, sympathomimetics, me-● peridine, dextromethorphan, anesthetic agents, CNS depres-● tricyclic antidepressants, carbamazepine, cyclobenzaprine, sants, antihypertensives, caffeine, and food with high tyramine ● content • Children younger than 16 years • Pregnancy and ● lactation (safety not established) ● 43 Orthostatic hypotension Nausea Blurred visionConstipation Disturbances in cardiac rate and rhythmDizziness Headache 7 • Patients with a history of seizures 1 10/1/10 9:39:25 AM 0 / 1 / 10 9 : 39 : 25 AM
