● ● ● ● ● ● ● Interactions● ● ●^438 system)Increased risk of suicidality in children and adolescents (black box warning) HypomaniaWeight g a i nSerious, potentially fatal adverse reactions may occur with concurrent use of other vasoconstrictors.cyclobenzaprine, bupropion, SSRIs, SARIs, buspirone, sympathomimetics, tryptophan, dextromethorphan, an-esthetic agents, CNS depressants, thiazide diuretics, Site reactions (itching, irritation) (with selegiline transdermal Avoid using within 2 weeks of each other (5 weeks after therapy with Hypertension or hypotension, coma, convulsions, and death Dry mouth21 days of MAOI therapy).Additive hypoglycemia may occur with Hypertensive crisis may occur with may occur with dopa, levodopa, dopamine, epinephrine, norepinephrine, guanethidine, methylphenidate, guanadrel, reserpine, Additive hypotension may occur with^ ●^ fl uoxetinePSYCHOTROPIC MEDICATIONS).opioidsor spinal anesthesia. (avoid use of antidepressants, carbamazepine, amphetamines, methyl-meperidineandantihypertensives, amphetamines. insulins wit hin 14 to or oral or
2 2506_Ch26_417-446.indd 1438 506 Ch 26 417 - 446 .indRoute and Dosage● Depression:● ISOCARBOXAZID● ● ● d other products containing high concentrations of (see Nursing Implications).DoxapramConsumption of foods or beverages with high Serotonin syndrome may occur with concomitant use of St. John’s wort.tent increases the risk of hypertension and arrhythmias.hypoglycemic agents.Bradycardia may occur with concurrent use of MAOIs and beta blockers.Hypertensive crisis may occur with ingestion of foods or effective dose. day divided into 2 to 4 doses. Gradually reduce to smallest of fiincrease dosage by 10 mg every 2 to 4 days to 40 mg by end increments of up to 20 mg/week. Maximum dosage: 60 mg/ 1438 rst week. If needed, may continue to increase dosage by may increase pressor response.^ PO^ (Marplan)^ : Initial dose: 10 mg 2 times a day. May caffeinetyramine con- 10/1/10 9:39:25 AM 10 / 1 / 10 9 : 39 : 25 AM
