BIOINORGANIC CHEMISTRY A Short Course Second Edition

206 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS

TABLE 5.3 X - Ray Crystallographic Structures of K

+ Channels

Species

K

+ Channel

Type

Number of aa

Residues/

Molecular Mass

(kDa)

PDB Accession

Number,

Resolution ( Å )

Chapter 5 ReferenceNumber

Year of

Publication

Chapter 5 and

Reference

Figure Numbers

Activation Gate Open/

Closed

Streptomyces lividans

(KcsA)

Weakly voltage -

dependent

K

+ channel 97/10.3

1BL8, 3.02

15

1998

5.5A, 5.5B

Closed

Rattus norvegicus

(Kv1.1)

Voltage -

dependent

Kv

β 2 subunit 332/37.2, T1 domain 103/13.2

1EXB, 2.10

16

2000

5.6, Figure 5,

reference 16

a

Streptomyces lividans

(KcsA)

Weakly voltage -

dependent

K

+ channel

b

124/13.2

1K4C, 2.00

1K4D, 2.30

17

2001

Closed

Methanothermobacter

thermautotrophic(MthK)

Ca

2+

• gated

K

+ channel 336/37.4

1LNQ, 3.30

23

2002

Open

Methanothermobacter

thermautotrophic(MthK)

Ca

2+

• gated

K

+ channel 234/25.9

2AEF, 1.70

(with Ca

2+

)

2AEJ, 2.10 (withoutCa

2+

) 2AEM.

2.80 (RCK domain)

Footnote c

c

2005

Aeropyrum pernix

(KvAP)

Voltage -

dependent

K

+ channel

b

223/24.3

1ORQ, 3.20

(containsY46Cmutation)

18, 25

2003

5.7, 5.8 Figures

3a, 3c, and 8, reference 18 Figures 5a and 5b, reference 25

Open