BIOINORGANIC CHEMISTRY A Short Course Second Edition

POTASSIUM-DEPENDENT MOLECULES 207

Species

K

+ Channel

Type

Number of aa

Residues/

Molecular Mass

(kDa)

PDB Accession

Number,

Resolution ( Å )

Chapter 5 ReferenceNumber

Year of

Publication

Chapter 5 and

Reference

Figure

Numbers

Activation Gate Open/

Closed

Aeropyrum pernix

(KvAP)

Voltage -

dependent

K

+ channel

b

132/14.6

1ORS, 1.90

18, 25

2003

Open

Burkholderia

pseudomallei(KirBac1.1)

Inward -

rectifi

er

K

+ channel with cytosolic domains337/37.2

1P7B, 3.65

2003

Closed

Rattus norvegicus

(Kv1.2)

Voltage -

dependent

K

+ channel with other subunits (T1 domain) 499/56.8;

β^2

subunit333/37.3

2A79

19, 37, 38

2005

Figures 2c and

4b, reference 37 Figures 3c, 3d, and 4, reference 38

Open

Aeropyrum pernix

(KvAP)

Voltage -

dependent

K

+ channel

d

241/26.2

2A0L

20

2005

Open

Streptomyces lividans

(KcsA) synthetic gly77 -

d - ala mutant

Voltage -

dependent

K

+ - channel

b,e

mutationsS69A and V70C

2IH1, 2.40

21

2006

Open

Streptomyces lividans

(KcsA) synthetic gly77 -

d - ala mutant

Voltage -

dependent

K

+ - channel

b,e

mutationsS69A and V70C

2IH3, 1.72

21

2006

Open

a In Figure 5 of reference 16, the pore region is based on the KcsA K

+ channel from PDB: 1BL8.

b Co - crystallized with Fab monoclonal antibodies from mouse. c Dong, J.; Shi, N.; Berke, I.; Chen, L.; Jiang, Y.

J. Biol. Chem

., 2005,

280

, 41716 – 41724.

d Co - crystallized with Fv monoclonal antibody fragments from mouse. e Low [K

+ ] for 2IH1; high [K

+ ] for 2IH3.