INDEX 479
Apoenzyme, 44
Acquired drug resistance (ADR), 43,
55
Area detectors, 95–96
Arginine, 32f, 57f, 151
Ca2+-ATPase and, 333
calmodulin and, 316, 321
cytochrome c and, 415, 421f
methane monooxygenase and, 459
Na+/K+-ATPase and, 203
potassium ion channels and, 214–218,
221–222, 226–227, 229, 232–234
zinc fi ngers and, 68–69
Arsenic (As), 2, 2t
Ascorbate oxidase, 461
Asparagine (Asn, N) 31f, 56
cytochrome c and, 410, 411
Aspartic Acid, aspartate (Asp, D),
32–33, 32f, 33f
aconitase and, 454, 455f, 457t,
456–458
Ca2+-ATPase and, 328–329, 331–332,
332f, 332t, 333–337
calmodulin and, 303, 303f, 305, 312f,
312t, 319, 322, 326
cytochrome bc 1 and, 399, 402–406,
406f
cytochrome c and, 388
cytochrome c oxidase and, 425, 429,
429–432, 433f
cytochrome P450 and, 364f, 368, 370f,
371–372
matrix metalloproteinase and, 120,
121f
methane monooxygenase and, 459
Na+/K+-ATPase and, 200–202
potassium ion channels and, 214, 216,
217f, 221, 223, 227, 230–231
P-type ATPases and, 327–329
zinc fi ngers and, 68, 71, 71f, 72t
Associative mechanism (A, SN2), 10
Ca2+-ATPase and, 335–337
ribozymes and, 258–262, 264, 268,
272, 279, 283–284, 286–287, 294,
296–297, 300
Atomic Force Microscopy, 139–143
A-T pairs, 47, 49, 50f, 141, 254f
ATP, see adenosine triphosphate
ATP analogs, 329, 333–334
ATPases, see also Ca2+-ATPase, Na+/K+
ATPase, 44– 45, 95–97, 383
A-U pairs, 49, 249, 253, 254f, 261, 263,
285, 297
AU / TG codon, 56
Automated sequencing technology,
61– 62
Avogad ro’s nu mb er, 13
Azurin, 4, 57–58B 12 see also coenzyme B 12 , cobalamin,
vitamin B 12 , 6t
Back-bonding, 346, 347f
BamHI, restriction enzyme, 59
Barium (Ba), 191t, 193, 195
Base-pairing, nucleic acids
Hoogsteen, 49, 244, 257
Watson-Crick, 47–50, 50f, 240f, 244,
253, 263, 285–286, 297
Bases, see nucleobases
B DNA, 47, 50, 52f, 53t, 66
Beryllium (Be), 11t, 190t
Beta pleated sheet, 34–35, 36f, 37f
cytochrome c and, 409
in lysozyme and, 37f, 38
in zinc fi ngers and, 64–65, 65f, 67, 70f,
72
parallel, antiparallel, 36f, 37f
β-mercaptoethanol(BME) thiolate,
373
Bioavailabilility of metal ions, see
homeostasis
Bioorganometallic chemistry, 19–22
16 –18e rule, 19–20, 19t, 20f
iron-sulfur clusters, 21–22
Bohr effect, see hemoglobin
Bohr magneton, 122
Boltzmann distribution, 100, 124
Boltzmann equilibrium, 109
Bone, 44, 140, 191t, 192, 194
Bragg’s law, 79–80, 88–89, 92
Brookhaven protein data bank, see
Protein Data Bank, PDBCa2+-ATPase, 191t, 200, 201
aspartylphosphate, 329, 337
Ca2+-ATPase cycle, 328f, 329–337
calcium binding, 329–333, 336 –337
calcium pump, 96, 190t, 319–321, 329