480 INDEX
comparison to Na+/K+-ATPase,
201–203
EF hand, 191t, 302–304, 306, 319,
324, 326
homeostasis and, 194–195
introduction to, 301, 327–329
thapsigargin and, 329, 331, 335, 336
X-ray crystallography, 96 –97, 330 –
337, 330f, 332f, 332t
Cadmium (Cd), 2, 7t, 174
calcium homeostasis and, 195
hammerhead ribozyme folding and,
290
Mg2+ substitute in ribozymes, 267t
PS rescue experiment and, 242, 268,
280–283, 288
Calcium ion, see also Ca2+-ATPase,
calmodulin, troponin
biological distribution, 3, 4t, 44, 191t,
193, 197, 204, 301
calcium pump, 96, 190t, 319–321, 329
coordination chemistry, 4t
homeostasis, 194–195, 199
in Ca2+-AT Pa se, 9 5 – 9 7, 3 01, 32 7–337,
330f, 332f, 332t
in calmodulin, 301–327
in matrix metalloproteinase, 120, 121f
in troponin, 301, 302
ion channels and, 204, 215
ligand preferences, 4t
phosphate minerals in bone, 191t,
192–193, 194, 199
Calmodulin:
apo-calmodulin, 304–309, 305f, 307f,
309t
Ca2+ binding, 194, 195, 301–304, 306–
308, 306f
drug interactions, 308–313, 312f
introduction to, 302–303
KAR-2 and, 311–313, 311f
NMR solution structures, 306 –308,
319
peptide binding to, 313–326, 314–
315t, 318f
trifl uoperazine and, 308–313, 310f,
312f
vinblastine and, 311–313, 311f
X-ray crystallography, 303–308, 305f,
323–325
Calsequestrin, 301–302
Capped porphyrin, see porphyrin
Carbon Dioxide, 43, 45
Bohr effect and, 192
Carbon Monoxide:
as a ligand, 7t, 8, 16, 19, 20
binding to iron porphyrins, 353, 357–
358, 357f
binding to hemoglobin and
myoglobin, 349–350, 356 –359(^13) C NMR, 105f
cytochrome P450 and, 361
cytochrome c oxidase and, 440, 445
distal histidine interactions, 357,
357f
fl ash photolysis from CcO, 145
organometallics and, 20–21
spectrochemical series and, 16
time-resolved crystallography,
14 6 –14 8
(Carbonmonoxy)hemoglobin, 349,
356 –359
(Carbonmonoxy)myoglobin, 349,
356 –359
Carboxypeptidase, 40
Carboxyl group, carboxylate, see also
aspartic acid, glutamic acid, 4t,
5t, 6t, 9t
biotin and, 220f
citrate, isocitrate and cis-aconitate,
451, 451f
peptides, 30, 32, 34, 34f, 40, 42
Catalase, 82, 366, 371, 372, 378, 380
Catalysis:
catalyst, 22, 29–30, 162, 262, 272, 300,
366, 369, 378, 378f, 464
enzyme catalysis, 4, 6t, 29–30, 172,
191t
organometallic, 22
ribozymes and, 240, 241, 243–244,
247, 249–250, 262–263, 268,
272–278, 280–281, 283–284,
286–292, 296–301, 336
transition state, 171, 227, 242–244,
258, 260f, 261–262, 268, 272,
275–278, 275f, 281–288, 292–293,
296, 300–301, 334–336
Catalytic RNA, see ribozyme(s)
CD, see circular dichroism