INDEX 493
descriptive examples, 167–170
hammerhead ribozyme and, 284–285
Na+/K+ ATPase and, 202–203
potassium ion channels and, 225
Molybdenum (Mo):
characteristics of, 6t
in nitrogenase, 4, 6t, 14, 19–20
Monooxygenases, see also cytochrome
P450, methane monooxygenase,
22, 172, 372–382, 455–461
Monte Carlo method, 165–166, 166f
MOPAC, 176, 179, 182
Mössbauer spectroscopy:
applications, generally, 132
characteristics of, 132–134, 133f
descriptive examples, 137–139
iron-sulfur clusters, 137–139
isomer shift (δ), 134–135, 135t
magnetic hyperfi ne interactions,
136–137
nitrogenase, 137–139
quadrupole splitting (ΔEQ), 134–135,
135t
Multiple-wavelength anomalous
dispersion (MAD), 92–93, 95,
241, 247, 464–465
μ-oxo iron species, 346, 350, 353–355,
354f, 355f
Mutagenesis, site-directed, 56–58, 83,
205, 220, 222, 224–225, 249, 344–
345, 349, 353, 425
Mutations, genetic, 56–58
Myoglobin, 3, 5t, 8, 17, 30, 43, 82, 83,
166 –167
active site, 350–351
carbon monox ide binding, 14 6 –14 8,
167, 356 –358
basics, 344–347
cytochrome P450 model and, 363,
372, 382
deox y-, 147–14 8, 34 4
diox ygen binding, 14 6 –147, 34 4, 34 6f,
349
EPR and, 127
ferryl-oxo iron intermediate, 354, 364,
371, 376
fl ash photolysis, 146 –147
ligands and, 344, 344f, 347, 350–352,
351t
met- 346, 349, 353
model compounds, 354–355
Mössbauer spectroscopy and 135t
μ-oxo iron species, 353–355, 354f, 355f
oxy-, 346, 349, 350 –352, 351t, 352t,
353–355
time-resolved crystallography and,
14 6 –14 8
X-ray crystallography, 344, 346, 349,
356 –359NAD, see nicotinamide adenine
dinucleotide
NADP, see nicotinamide adenine
dinucleotide phosphate
Na+/K+-ATPase, 44, 45, 190t, 191t,
199–203
active transport and, 197–199
facilitated diffusion and, 197
X-ray crystallography and, 200 –203
National Cancer Institute (NCI),
184 –185
National Human Genome Research
Institute, 61–62
National Institutes of Health (NIH), 62,
97, 182
National Library of Medicine, 184–185
nephelauxetic effect, 103
Neural network, 39, 165
Newton-Raphson method, 165
Nickel (Ni):
characteristics of, 2t, 16
effect of Ni(II) on dsDNA, 141
ligand geometry, 6t, 16, 81
Nicotinamide adenine dinucleotide
(NAD), 44, 44f, 388
Nicotinamide adenine dinucleotide
phosphate (NADP), 24, 24f,
212
Nitrogen (N 2 ), 2t, 5t
Nitrogenase, 4, 5t, 6t, 22, 33, 137–139,
166, 450
iron-sulfur clusters, 137–139
ENDOR studies, 137–139
M center (FeMoco), 137f
Mössbauer spectroscopy, 137–139
X-ray crystallography, 139
Nonallosteric enzymes, 44– 46, 46f
Noncompetitive inhibitors, 46–47