Manual of Clinical Nutrition

Food and Drug Interactions

Manual of Clinical Nutrition Management II- 28 Copyright © 2013 Compass Group, Inc.

Medication

Classification

Effect of Food

on Medication

Effect of Medication on

Nutritional Status

Patient Guidelines

Linezolid (Zyvox)

Possible

interaction with

foods and

beverages with

high tyramine

content (2)

Linezolid is an oxazolidinone

antibiotic possessing weak,

reversible monoamine oxidative

inhibitor activity.

Avoid high tyramine containing foods
during use. This IV antibiotic is
primarily used in the hospital setting
when typically lower tyramine foods
are consumed. A recent study
showed dietary restriction is often
not necessary due to lower tyramine
content of the hospital meals (3).
However, FDA recommends avoiding
consuming large amounts of foods or
beverages with high in tyramine
content during use (2).
Ciprofloxacin
(Cipro)

Patients taking sulfasalazine may

require a supplement of 1 mg/day of

folic acid to prevent vitamin

deficiency associated with

competition of the medication for

absorption of folate

Possible  vitamin K and vitamin B

absorption

Take multivitamins with minerals,

Ca, Fe, Mg separately by 2 hours

Stop tube feeding 2 hours before and

2 hours after medication intake

Sulfasalazine

Antifungal
Griseofulvin
(Fulvicin)

Fulvicin

absorption

improves with a

fatty meal or

whole milk

Taste loss; oral candidiasis; dry

mouth; stomach pain

Take with whole milk or meal

Antihyperlipidemic
Clofibrate
(Atromid-S)

Nausea

Reported decreased absorption of

vitamins A, D, K, B 12 , folate, and Fe

Take with food or milk
Follow a low-cholesterol and low-fat
diet
Colestipol
(Cholestid;
Probucol)
Cholestyramine
(Questran,
Cuemid)

Constipation common Increase intake of water and high-
fiber foods
Take with meals
Take vitamin/mineral supplements 1
hour before or 4 hours after
medication intake
Atorvastatin
(Lipitor)
Lovastatin,
(Mevacor, Altocor)
Simvastatin
(Zocor)

Consuming high-

fiber foods at same

time medication is

taken 

absorption of

medication

Grapefruit juice

may increase

medication

availability and

absorption (4-7)

St. John’s Wort

can reduce the

concentration of

medications in

blood (8)

Mevacor: Do not consume with high-

fiber foods

Avoid grapefruit juice (4-7).

Mevacor and Altocor:

Avoid St. John’s Wort (8)