xxi11 Personalized Management of Infectious Diseases ................................ 383
Introduction ............................................................................................... 383
Personalized Management of Bacterial Infections ................................... 383
Bacterial Genomics and Sequencing .................................................... 383
Role of Rapid Molecular Diagnosis at Point of Care ........................... 385
Personalized Vaccines Against Bacterial Infections ............................. 385
Personalized Management of Sepsis ..................................................... 386
Personalized Management of Tuberculosis .......................................... 386
Personalized Management of Viral Infections .......................................... 387
Personalized Approach to Management of HIV ................................... 388
Personalized Treatment of Hepatitis B ................................................. 401
Personalized Treatment of Hepatitis C ................................................. 402
Personalized Management of Fungal Infections ....................................... 405
Personalized Management of Malaria ...................................................... 406
Genomics of Malaria ............................................................................. 406
References ................................................................................................. 407
12 Personalized Management of Neurological Disorders ......................... 409
Introduction ............................................................................................... 409
Neurogenomics ......................................................................................... 409
Applications of Neurogenomics in Neurological Disorders ................. 410
Impact of Neurogenomics on the Development
of Personalized Neurology .................................................................... 412
Epigenomics/Epigenetics ...................................................................... 412
Neuroproteomics ....................................................................................... 413
Applications of Neuroproteomics for Study
of the Nervous System .......................................................................... 413
CSF Tests Based on Proteomics ............................................................ 414
Diagnosis of Neurologic Disorders by Examination of Proteins
in the Blood ........................................................................................... 414
Role of Proteomics in Neuropharmacology .......................................... 416
Neurometabolomics .................................................................................. 417
Diagnosis-Guided Therapies for Neurological Disorders ......................... 417
Personalized Biological Therapies for Neurological Disorders ................ 417
Personalized Management of Alzheimer Disease ..................................... 418
Introduction to Alzheimer Disease ........................................................ 418
Diagnosis of AD .................................................................................... 418
Genomic Basis of Personalized Approach to Alzheimer Disease ......... 420
Prospects for the Future Management of AD ....................................... 421
Personalized Management of Parkinson Disease ..................................... 421
Genomic Basis of Personalized Approach to Parkinson Disease ......... 421
Role of Pharmacogenetics in Personalizing Therapy of PD ................. 423
Discovery of Subgroup-Selective Drug Targets in PD ......................... 423
Personalized Cell Therapy for PD ........................................................ 424
Contents