33Goldberger JJ, Buxton AE. Personalized medicine vs guideline-based medicine. JAMA. 2013;
309:2559–60.
Hastings PJ, Lupski JR, Rosenberg SM, Ira G. Mechanisms of change in gene copy number. Nat
Rev Genet. 2009;10:551–64.
Jain KK. Health care in New China. Emmaus: Rodale Press; 1973.
Jain KK. Personalized medicine. Waltham: Decision Resources Inc; 1998.
Jain KK. Personalised medicine. Curr Opin Mol Ther. 2002;4:548–58.
Jain KK. Synthetic biology and personalized medicine. Med Princ Pract. 2013;22:209–19.
Kalow W. Familial incidence of low pseudocholinesterase level. Lancet. 1956;2:576–7.
Kalow W. Pharmacogenetics: heredity and the response to drugs. Philadelphia: Saunders; 1962.
Kidd JM, Cooper GM, Donahue WF, et al. Mapping and sequencing of structural variation from
eight human genomes. Nature. 2008;453:56–64.
Korbel JO, Urban AE, Affourtit JP, et al. Paired-end mapping reveals extensive structural variation
in the human genome. Science. 2007;318:420–6.
Lee KH, Chiu S, Lee YK, et al. Age-dependent and tissue-specifi c structural changes in the
C57BL/6J mouse genome. Exp Mol Pathol. 2012;93:167–72.
Lupski JR, Belmont JW, Boerwinkle E, Gibbs RA. Clan genomics and the complex architecture of
human disease. Cell. 2011;147:32–43.
Marshall A. Genset-Abbott deal heralds pharmacogenomics era. Nat Biotechnol. 1997;15:
829–30.
Mills RE, Luttig CT, Larkins CE, et al. An initial map of insertion and deletion (INDEL) variation
in the human genome. Genome Res. 2006;16:1182–90.
Mirnezami R, Nicholson J, Darzi A. Preparing for precision medicine. N Engl J Med. 2012;366:
489–91.
Motulsky AG. Drug reactions, enzymes and biochemical genetics. JAMA. 1957;165:835–7.
Mullis K, Faloona F, Scharf S, et al. Specifi c enzymatic amplifi cation of DNA in vitro: the poly-
merase chain reaction. Cold Spring Harbor Symp Quant Biol. 1986;51:263–73.
Nielsen J. Translational and systems medicine. J Int Med. 2012;271:108–10.
Redon R, Ishikawa S, Fitch KR, et al. Global variation in copy number in the human genome.
Nature. 2006;444:444–54.
Romanoski CE, Lee S, Kim MJ, et al. Systems genetics analysis of gene-by-environment interac-
tions in human cells. Am J Hum Genet. 2010;86:399–410.
Skipper M, Dhand R, Campbell P. Presenting ENCODE. Nature. 2012;489:45.
Solomon BD, Nguyen AD, Bear KA, Wolfsberg TG. Clinical genomic database. Proc Natl Acad
Sci U S A. 2013;110:9851–5.
Sudmant PH, Kitzman JO, Antonacci F, et al. Diversity of human copy number variation and mul-
ticopy genes. Science. 2010;330:641–6.
Vandamme D, Fitzmaurice W, Kholodenko B, Kolch W. Systems medicine: helping us understand
the complexity of disease. QJM. 2013;106:891–5.
Vogel F. Moderne Probleme der Humangenetik. Ergeb Inn Med Kinderheilkd. 1959;12:52–125.
Watson JD, Crick FHC. Genetic implications of the structure of deoxyribonucleic acid. Nature.
1953;171:964–9.
Wilkins MR, Sanchez JC, Gooley AA, et al. Progress with proteome projects: why all proteins
expressed by genome should be identifi ed and how to do it. Biotechnol Genet Eng Rev.
1995;13:19–50.
Wist AD, Berger SI, Iyengar R. Systems pharmacology and genome medicine: a future perspec-
tive. Genome Med. 2009;1:11.
References