days, if already chronically
low
Renal Acute Kidney Injury (AKI):
Creatinine ≥ 2 times normal
for age
OR Doubling of the baseline
creatinine
Hepatic Hyperbilirubinemia (>4
mg/dl) *excluding newborns
OR: ALT ≥ 2 times normal for age
III. Treatment of Sepsis
Historically, goals of therapy in pediatric sepsis were adapted from the
adult guidelines, which themselves were originally defined in the 2004 Surviving
Sepsis Campaign. These guidelines have since been revised, both in 2007 and
2012, with the most recent publication defining more realistic goals for the
pediatric population, particularly in severe sepsis and septic shock. The