ECMO-/ECLS

o Effects on CNS to decrease sympathetic tone,

stimulates central parasympathetic outflow, decreases

sympathetic outflow.

o Induces natural REM sleep and is associated with rapid

and easy arousal.

 Dosing: 0.2-0.7mcg/kg/hour. Bolus 0.3-1 mcg/kg

 Elimination: Half life 1.5 – 3 hours

 Precautions: Bolus dosing can cause rapid, transient

decrease in heart rates and increased blood pressure. At

lower doses reduction in blood pressure.

 Adverse effects: bradycardia, sinus arrhythmias, heart block,

nausea and vomiting

 Relative contraindications: hemodynamically unstable

patients; moya moya disease or patients who have had a

stroke; concomitant use of clonidine

V. Common Anesthetics

A. Systemic Anesthesia