- Propofol [13,17]^
2,6 di-isopropylphenol, an alkylphenol IV general anesthetic
Clinical indications: Use as sedative to facilitate short term
mechanical ventilation and procedures
Clinical effects: Dose-proportional sedative/anesthetic effects
o Clinical effects dissipate quickly with discontinuation of
infusion
o Negative ionotropic effects
o Potent vasodilator
Dosing: initial bolus 1-2 mg/kg. Infusion 75-250 mcg/kg/minute
Onset & elimination: Rapid onset – within a minute of
injection.
o 3 compartment pharmacokinetics – blood, rapidly
equilibrating tissue (i.e. brain), slowly equilibrating
tissue. Rapid distribution in blood & rapid clearance,
which is responsible for short duration of action. Short
distribution half life, long elimination half life.
Precautions: Avoid use >12 hours in critically ill children
o Risk of propofol infusion syndrome with prolonged use
causes lactic acidosis, hyperlipidemia,
bradyarrhythmias, myocardial failure & potential risk of
death
marcin
(Marcin)
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