Noncompetitive binding of acetylcholine receptor at motor end plate
causing interruption of nerve impulse transmission. No sedative or
analgesic effects.- Succinylcholine
fast onset (<1 minute), 3-5 minute duration of action
Depolarization causes fasciculations which causes increase in
intragastric, intraocular, and intracranial pressures
Can have prolonged neuromuscular blockade if have
pseudocholinesterase deficiency, pregnancy, liver dysfunction,
or hypermagnesia
Side effects: lethal hyperkalemia, severe bradycardia,
myalgia, increased intracranial pressure
Not recommended for routine use
B. Non-depolarizing [13]^
Competitive binding of post-synaptic nicotinic acetylcholine receptors
produces neuromuscular blockade. No sedative or analgesic effects.
Occupation of 60% of receptors does not result in any weakness or
paralysis. Occupation of 95% of receptors will result in inability to
swallow, cough or protect airway, however can still take normal tidal
volume