PDR for Herbal Medicines

(Barré) #1
HERBAL MONOGRAPHS ST. JOHN'S WORT/723

Wounds, bruising and swelling: The herb is applied topically
and locally for treatment. The activity of the topical
preparations is based on the hyperforin content, which is
highly variable depending on the method of oil preparation.
The preparation may be stable for a few weeks up to 6
months. (Maisenbacher & Kovar, 1992)
Homeopathic Dosage: The daily dosage for homeopathic
indications is 5 drops, 1 tablet or 10 globules every 30 to 60
minutes for acute therapy, and 1 to 3 times daily for chronic
use. Parenterally, 1 to 2 ml subcutaneously administered
three times daily for acute therapy and once daily for chronic
therapy. The ointment is applied 1 to 2 times daily for acute
and chronic use (HAB1).
Storage: Store at room temperature, away from heat,
moisture and direct light. Hyperici oleum has a limited shelf
life. One study showed that a sample containing 62
milligrams of hyperforin (the active ingredient in the oil)
contained no hypericin in 14 days. If sunlight is not used to
prepare the oil, then the breakdown is slower, but still less
than 30 days. Various oil preparation methods have been
described, including one with eutanol G, which showed
stability for 6 months. Researchers evaluated^ 6 commercial
samples of oil of Hypericum containing 2.2 to 20.8
milligrams/deciliter. All hyperforin was gone by the end of
five weeks (Maisenbacher, 1992).
LITERATURE
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photosensitization caused by the ingestion of St. John's Wort
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and Constiuents of Hypericum Extract. J Geriatr Psychiatry
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treated with St. John's Wort, The Lancet 1998;352:1121-1122.
Butterweck V et al.. Isolation by MLCCC and NMR
spectroscopy of hypericin, pseudohypericin and 13,118-biapigenin
from Hypericum perforatum. In: PM 62, Abstracts of the 44th
Ann Congress of GA, 119. 1996.

Butterweck V, Winterhoff H, Schulz V, Nahrstedt A,
Pharmacological in vivo testing of fractions obtained from


Hypericum perforatum L. In: PM 62, Abstracts of the 44th Ann
Congress of GA, 65. 1996.
Carpenter S, Kraus GA, Photosensitization required for
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Photochem Photobiol 53:169-174. 1991.
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Fachinformation: Helarium (R) Hypericum, hypericum extract.
Bionorica GmbH, Neumarkt, 1996.
Fachinformation: Remotiv (R), hypericum extract. Bayer AG,
Pharma Deutschland, Leverkusen, 1996.
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studies of hypericum, the active compound in St. John's Wort,
as an antiretroviral agent in HIV-infected adults. AIDS clinical
trials group protocols 150 and 258. Ann Intern Med 1999 Mar
16;130(6):510-4.
Hansel R, Keller K, Rimpler H, Schneider G, (Hrsg.), (1993)
Hagers Handbuch der Pharmazeutischen Praxis, 5. Auflage,
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study examining the antidepressant effectiveness of the
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eines hochdosierten Hypericum-Extraktes. Miinch Med Wschr
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pflanzliches Antidepressivum. Nervenheilkunde 12:268-366.
Harrer G, Schulz V, (1993) Zur Priifung der antidepressiven
Wirksamkeit von Hypericum. Nervenheilkunde 12:271-273.
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with Hypericum. Phytomedicine 1:3-8. 1994.
Harrer G, Schmidt U, Kuhn U, Biller A., Comparison of
equivalence between the St. John's Wort extract LoHyp-57 and
fluoxetine. Arzneimittelforschung 1999 Apr,(4):289-96.
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