0071483446.pdf

(^218) CHAPTER 13 Antimicrobials—Fighting Infection
First Generation: Effective against gram-positive bacteria
Pregnancy Category: B
Route Dose Time
Cefadroxil (Duricef)
Protein-Binding: 20%
Half-Life:^1 / 2 –2 hours
PO 500 mg Every 12 hours
Cefazolin (Ancef, Kefzol)
Protein-Binding: 75%–85%
Half-Life:^1 / 2 –2^1 / 2 hours
IV 0.25–1.5 g Every 6-8 hours
IM 1 g Presurgery
Cephalexin (Keflex)
Protein-Binding: 65%–80%
Half-Life: 0.5–1 hour
PO 250–500 mg Every 6 hours
Cephalothin (Keflin)
Protein-Binding: 10%–15%
Half-Life: 0.5–1.2 hours
IM/IV 0.5–1 g Every 4 to 6 hours
Cephapirin (Cefadyl)
Protein-Binding 40%–50%
Half-Life: 0.5–1 hour
IM /IV 0.5–1 g Every 4 to 6 hours
Cephradine (Velosef, Anspor)
Protein-Binding: 20%
Half-Life: 1–2 hours
PO 250–500 mg Every 8 hours
IM/IV 0.5–1 g Every 6 hours