CHAPTER 13 Antimicrobials—Fighting Infection^219
Second Generation: Increased activity against gram (−)
microorganisms
Pregnancy Category: B
Route Dose Time
Cefaclor (Ceclor)
Protein-Binding: 25%
Half-Life 0.5–2 hours
PO 250–500 mg Every 8 hours
IM/IV 500 g Every 6 hours
Cefamandole (Mandol)
Protein-Binding: 60%–75%
Half-Life: 0.5–1 hour
IM/IV 500 mg Every 6–8 hours
Cefmetazole (Zefazone)
Protein-Binding: 68%
Half-Life: 2.5–3 hours
IV 2g Every 12 hours
Cefonicid (Monocid)
Protein-Binding: 98%
Half-Life: 0.5–1.2 hours
IM/IV 0.5–1 g Every 24 hours
Cefotetan (Cefotan)
Protein-Binding: 85%
Half-Life: 3–5 hours
IM /IV 102 g Every 12 hours
Cefoxitin (Mefoxin)
Protein-Binding: 70%
Half-Life: 45 minutes–1 hour
IV 102 g Every 6 to 8 hours
Cefprozil (Cefzil)
Protein-Binding: 99%
Half-Life: 1–2 hours
PO 500 mg Every 12 hours