Quick Review Cards for Medical Laboratory Science

Antihuman Globulin Serum Immunohematology Review 459

TYPE DETECTS COMMENTS

Polyspecific (broad spectrum)

Monospecific
Anti-IgG

Anti-C3d or anti-C3b-C3d

Used for direct antiglobulin test (DAT). Some labs use for xmatch & ab

detection. If pos, monospecific sera used for follow-up testing. Advantage:

May detect complement-binding ab more readily. Disadvantage: Rxn

due to complement binding by clinically insignificant cold ab.

Can be used for routine compatibility tests & ab ID. Detects clinically

significant abs.

Helpful in investigation of immune hemolytic anemia.

IgG & C3d

IgG

Complement