Quick Review Cards for Medical Laboratory Science

Rh Immune Globulin (RhIG) Immunohematology Review 483

Composition

Purpose

Administration

Dose

Anti-D derived from pools of human plasma

Prevent immunization to D

Antepartum: To Rh neg woman at 28 wk of gestation

Postpartum: Within 72 hr of delivery when Rh-neg woman delivers Rh-pos baby

Other obstetric events: To Rh-neg woman after spontaneous or therapeutic abortion, ectopic pregnancy,

amniocentesis, chorionic villus sampling, antepartum hemorrhage, or fetal death

Note: May also be administered to Rh-neg recipients of Rh-pos blood or components

1 dose per 15 mL of D-pos fetal RBCs (30 mL of fetal WB). In calculating dose, if # to right of decimal point

is ≥0.5, round up to next whole # & add 1 vial, e.g., 1.6 vials calculated = 2 + 1 = 3. If # to right of decimal

point is <0.5, don’t round up; just use whole # & add 1 vial, e.g., 1.4 vials calculated = 1 + 1 = 2.