756 APPENDIX B DRUG FORMULARY
Drug name (trade orother names)Pharmacology andindicationsAdverse effects andprecautionsDosing information andcommentsFormulationsDosage (unlessotherwise indicated,dose is the same fordogs and cat)Cefdinir (Omnicef)Oral third-generationcephalosporin. Activityincludes staphylococci andmany gram-negativebacilli.Similar to those of othercephalosporins.Use in veterinary medicinehas not been reported.Use and doses areextrapolated from humanmedicine.300 mg capsules,25 mg/mL oralsuspension.Dose not established.Human dose is 7 mg/kgq12h po.Cefixime (Suprax)Cefixime is athird-generationcephalosporin.Similar to those of othercephalosporins.Although not approvedfor veterinary use,pharmacokinetic studiesin dogs have providedrecommended dosages.20 mg/mL oralsuspension and 200and 400 mg tablets.10 mg/kg q12h po; forcystitis: 5 mg/kg q12–24hpo.Cefotaxime sodium(Claforan)Cefotaxime is athird-generationcephalosporin. It is usedwhen resistance isencountered to otherantibiotics or wheninfection is in centralnervous system.Similar to those of othercephalosporins.Third-generationcephalosporin used whenresistance encountered tofirst- andsecond-generationcephalosporins.500 mg; 1, 2, and10 g vials forinjection.Dog: 50 mg/kg IV, IM, SCq12h.Cat: 20–80 mg/kg q6h IV,IM.Cefotetan disodium(Cefotan)Cefotetan issecond-generationcephalosporin.Similar to those of othercephalosporins.Second-generationcephalosporin similar tocefoxitin, but may havelonger half-life in dogs.1, 2, and 10 g vialsfor injection.30 mg/kg q8h IV, SC.Cefoxitin sodium(Mefoxin)Cefoxitin is asecond-generationcephalosporin. May haveincreased activity againstanaerobic bacteria.Similar to those of othercephalosporins.Second-generationcephalosporin, which isoftenusedwhenactivityagainst anaerobic bacteriais desired.1, 2, and 10 g vialsfor injection.30 mg/kg q6–8h IV.