Small Animal Dermatology, 3rd edition

812 APPENDIX B DRUG FORMULARY

Drug name (trade orother names)

Pharmacology andindications

Adverse effects andprecautions

Dosing information andcomments

Formulations

Dosage (unlessotherwise indicated,dose is the same fordogs and cat)

Terbinafinehydrochloride (Lamisil)

Antifungal drug effectiveagainst dermatophytesand

Malassezia

.

Vomiting and anorexia.Hepatotoxicity possiblebut not reported inanimals.

Doses used in dogs andcats much higher thanthose used in humans.

250 mg tablets, 1%topical solution, 1%topical cream.

Dog: 30 mg/kg po (withfood) q24h for 3 weeks.Cat: 30–40 mg/kg poq24h for at least 2 weeks.

Testosterone cypionateester (Andro-Cyp,Andronate,Depo-Testosterone,and other forms) andTestosteronepropionate ester(Testex [Malogen inCanada])

Testosterone ester. Similareffects asmethyltestosterone.Testosterone esters areadministered IM to avoidfirst-pass effects. Esters inoil are absorbed moreslowly from IM injection.Esters are then hydrolyzedto free testosterone.

Adverse effects areattributed to androgenicand anabolic effects.Hepatic toxicity is alsopossible.

Clinical efficacy forchronic diseases has notbeen evaluated in smallanimals.

Testosteronecypionate 100,200 mg/mLinjection.Testosteronepropionate100 mg/mLinjection.

Testosterone cypionate1–2 mg/kg every 2–4weeks IM (see alsoMethyltestosterone).Testosterone propionate0.5–1 mg/kg 2–3times/week IM.

Tetracycline (Panmycin) Tetracycline antibiotic.

Tetracyclines bind to 30Sribosomal subunit andinhibit protein synthesis.Usually bacteriostatic.Broad spectrum of activity,including bacteria, someprotozoa,

Rickettsia

,

Ehrlichia

.

Tetracyclines in generalmay cause renal tubularnecrosis at high doses.Tetracyclines can affectbone and teeth formationin young animals.Tetracyclines have beenimplicated in drug fever incats. Hepatotoxicity mayoccur at high doses insusceptible individuals.Drug interactions

:

Tetracyclines bind tocalcium-containingcompounds, whichdecreases oral absorption.

Pharmacokinetic andexperimental studies havebeen conducted in smallanimals, but no clinicalstudies. Do not useoutdated solutions.

250, 500 mgcapsules;100 mg/mLsuspension.

15–20 mg/kg q8h po; or4.4–11 mg/kg q8h IV, IM.