A:T base pair
minor groove electrostatic
potential 361
structure 7
abacavir 130
acceptor stem
tRNA structure 275, 420
2-acetylaminofluorene
structure 304, 305
transversion mutations 332
acridines
intercalation into DNA 349
actinomycin D 125
acyclonucleosides
synthesis 90
adenine
nucleosides & nucleotides 15–16
structure 14
adenine, 3-alkyl
DNA alkylation 324
adenosine deaminase
ADAR family 270, 271
A-DNA
comparison with DNA-RNA
hybrid 385
secondary structure 25, 27, 30
ADP, adenosine 5-diphosphate
synthesis 113
alkaline phosphatase 174
allele 222
alternative splicing
mRNA biosynthesis 266
Altman, R.
nucleic acid research 2
Alu family
DNA 247, 280
Alzheimer’s disease
8-oxoguanine DNA glycosylase 329
AMP, adenosine 5-monophosphate
biosynthesis 118
structure 15
aminoacyl tRNA
protein synthesis 275–276
2-aminopurine nucleosides
synthesis 96
analytical ultracentrifugation,
AUC 439–441
circular DNA 440
sedimentation equilibrium 440–441
sedimentation velocity 440
sucrose gradient
RNA analysis 441
anthracycline
DNA binding 350, 357
antibiotics
enediyne
Bergman cyclisation 312, 313
calicheamicin 1 312, 315
neocarzinostatin 312
anticancer agent
brain tumour &
Temozolomide 308, 310, 326
first generation 308
mitomycin C 309, 310
Mylotarg™ 314
second generation 309
sequence-specific DNA binding 314
Phortress 306
anticancer chemotherapy 125, 326
anticancer drugs
reactions with nucleic acids 308–316
anticodon loop
tRNA structure 258
antigene therapy
TFO, triplex forming oligonucleotide
373
antimetabolites 126
antisense DNA 59, 60
antisense oligonucleotides
mechanism of action 193, 195
antisense RNA
DNA•RNA heteroduplex structure 59
natural targetting 283
antiviral agents
phosphonoformic acid 136
ribavirin 135
antiviral chemotherapy 129–135
acyclovir 133
adefovir dipivoxil prodrug 134
agents in clinical use 130
combination therapy 131
drug design 133
famciclovir 134
host-cell receptor-based 132
penciclovir 134
protease inhibitors 132
tenofir disoproxil prodrug 134
Ap 4 A
P^1 ,P^4 -diadenosyl
tetraphosphate 111, 116
apoptosis
by DNA damage 325
drug induced 314
telomere 375aptamer 198, 257
apurinic acid 296
arabinonucleosides
synthesis 98
aristeromycin
structure, synthesis 89, 90
A-RNA
duplex 254
secondary structure 57–58
A-RNA 57
ATP, adenosine 5-triphosphate
chemical synthesis 114
oxygen isotope enriched 115
structure 112
Avery, O.
bacterial transformation 1
aziridine antibiotics 310
AZT
3 -azido-2,3-
dideoxythymidine 82, 130
synthesis 98, 99globin gene 211, 214
bacteriophage 170
bacteriophage phi29
packaging motor 283, 285
pRNA 283, 285
Baker’s 1,2-transrule 85
base
misincorporation 332
base ratio 6
base tautomer 5, 299, 325
base mispairing
O^4 -methylthymine 325
base pair mismatch 36–38
insertion-deletion 38
repair 330
transition 37, 300, 319
transversion 37, 319
base pairing 6, 232, 256
quadruple interaction 257
triple interaction 256
base pair
‘wobble’ pair 18, 255, 325
A:C pair 255
alternative in RNA 255
bowing 33
clashing 34
G:U ‘wobble’ pair 255
Hoogsteen 18, 255, 373
mismatch 36, 331