460 Subject Index
base pair (contd)
separation 349
Watson-Crick 17
bases
amino-imino forms 299
electrostatic interactions 34
keto-enolforms 6, 18
mutagenic, 8-oxoguanine 328
non-instructional modification 332
–interactions 20, 31
base stacking 18, 350
stability matrix 65, 428
base triples
Hoogsteen 50
reversed Hoogsteen 50
B-DNA 25, 26, 30, 385
circular dichroism 431
Beaucage, S. 160
bent DNA 36, 40, 312
bifunctional alkylating agent
mustard gas 301
bioinformatics
DNA sequence 220–223
bisacridine 356
bisanthracycline 357
bisdaunomycin complex
structure 358
linker length modulation 356
–35 box 224
Brenner, S.
triplet code 7
B-Z junction
B-Z transition 45, 47
circular dichroism 431
energetics 67
C. elegans
miRNA precursor 284
C:G base pair 7, 260, 361
cadeguomycin
synthesis 96
Calladine’s rules 35, 386
cancer
bladder & aromatic amines 303, 305
colon & aflatoxins 308, 309
scrotal & benzo[a]pyrene 307, 308
skin cancer and photolesions 318, 322
testicular & cisplatin 302
cap structure 263
carbocyclic nucleosides
synthesis 88
carbonyl bisimidazole
condensing reagent 114
carcinogen
chrysene 307
dimethylnitrosamine 306, 307
embryonal 192
metabolic activation
reaction with nucleic acids 303–308
4-nitroquinoline N-oxide 306, 307
polycyclic aromatic hydrocarbons,
PAHs 307
proximate & ultimate 304
carcinoma cells 149, 153, 186
Caruthers, M. 226
catabolite activator protein, CAP 186
cDNA 222
cDNA library 306, 325
cell cycle arrest
2 ,3-dideoxynucleotides 297
chain termination
Chargaff’s rules 6, 7
Chargaff, E. 192
chimera 218
chloroplast
DNA intercalation 370
chloroquine
chromosome component 216, 218
chromatin 69, 216–219
‘active’ 230
packing 230, 345, 408
structure & gene expression 230, 379
structure 69, 70
chromosome 431–432
artificial – bacterial (BACs) 171, 222
artificial – yeast (YACs) 170, 222
centromere 216–9
ends 235
eukaryotic 217–218
jumping 173
metacentric 219
microdissection 172
segregation 217
telocentric 219
walking 170, 173
circular dichroism 431–432
circular DNA
AFM analysis 448
supercoiling 46, 47, 440
closed promoter complex 224
C-nucleosides
synthesis 86
codon 273, 274
reassignment 274
synonym 273
codon-anticodon interaction 255
co-enzyme A
structure, synthesis 112, 115
comparative genomic
hybridisation, CGH 188
control region
lacoperator 226
co-operativity
DNA-protein binding
DNA allostery 402
the chelate effect 402
in DNA ligand binding 372
cosmid 170
CpG-rich island 230
Crick, F.DNA structure 6
curved DNA 38, 409
2-cyanoethyl phosphates
in synthesis 103
cyclic ADP ribose 112
cyclonucleosides
synthesis 98
cyclophosphamide
anti-cancer agent 126, 128
cytidine, 2-deoxy
tautomerism 18
cytidine
nucleosides & nucleotides 14–16
synthesis of 2-modified 97
cytidine, 5-methyl
RNA minor nucleoside 272
cytosine
structure 14daunomycin A
DNA intercalation 350–352, 358
Debye-Hückel interactions 343
deoxyadenosine analogues
cladribine 126
fludarabine 126
2 -deoxyformycin A
MutY inhibition 329
2-deoxy-D-ribose
hydroxyl radical action 322
structure 3, 14
deoxyribonucleotide biosynthesis
ribonucleotide reductase 121
Dervan pairing rules 366, 367
Dervan, P.
footprinting 297, 366
didanosine, ddI
antiviral agent 130, 131
2 ,3-didehydro-2,3-dideoxy-
nucleosides
synthesis 99
2 ,3-dideoxynucleosides
synthesis 99
2 ,3-dideoxynucleoside 5-triphosphates
in sequencing 168
5,6-dihydropyrimidine nucleosides
synthesis 296
dihydrouridine
synthesis 296
tRNA structure 258
4,4-dimethoxytrityl, DMT
protecting group 145
dimethyl sulfate
DNA alkylation 204
DNA 24–52
aptamers 197
bent 332
blunt ends 174
bypass replication 332
catalytic 200, 201
catenated 49