462 Subject Index
DNA structure (contd)
I-motif 54
linear polynucleotide 4
non-canonical 52
palindromes 40, 41, 385, 392
sequence-dependence 28
slipped structures 40
twofold symmetry 6, 385
unusual 38
DNA-RNA hybrid 59–61, 385
NMR 434
DNAzyme 200, 201
Donohue, J.
keto-enol forms 7
D-ribose
structure 14
Eckstein, F.
phosphorothioates 160
elongation
prokaryotic transcription 224
enzymes
DNA
BamHI restriction endonuclease,
binding to DNA 400
3 -exonucleases 195, 331
gyrase 218, 416
helicase 234, 331, 413
human DNA glycosylases 327
integrase 220
Klenow fragment DNA pol I 168
ligase 176, 331
methyl transferases, Mtases,
SMILing DNA 430
polymerase 124, 220
polymerase III 234, 332
polynucleotide kinase 174
repair 325
restriction endonuclease 173, 176
telomerase 235, 376
thermostable DNA polymerase 168
topoisomerase 218, 232, 234
topoisomerase I 48
topoisomerase II 49
DNA repair
AP endonuclease 328
bacterial Ada protein 327
human MUTYH 329
O^6 -alkylguanine-DNA
alkyltransferase 129, 308
O^6 -methylguanine-DNA
methyltransferase 326
OGG1 329
8-oxoguanine DNA glycosylase 329
photolyase 326, 407
recBCD 332
uracil DNA glycohydrolase,
UDG 328, 406
metabolic
acetate transferase 304
cytochrome CYP1A1 307
cytochrome P-450 oxidase 303
epoxide hydrolase 307
sulfotransferase 304
nucleoside
adenosine deaminase 270
thymidine kinase 135
nucleotide
8-oxoGTP hydrolase 329
thymidylate synthase 122, 123, 298
phosphates
alkaline phosphatase 174
ribonucleotide
ribonucleotide reductase 121
RNA
Dicer, RNA endonuclease 198, 283
eukaryotic RNA polymerases 226
poly-A polymerase 264
reverse transcriptase 124, 170, 220
ribonuclease A 106
RNA debranching 273
RNA exonuclease 273
RNA polymerase 220, 263
RNAse H 194, 233
RNAse III 268
RNase P 268
RNA polymerase – viral 224
RNA polymerase I 227, 231
RNA polymerase II 227
RNA polymerase III 231
RNA primase 233
tRNA
aminoacyl tRNA synthetases 275
aminoacyl tRNA synthetases,
class I 275–276, 419
aminoacyl tRNA synthetases,
class II 276, 419
ethidium bromide
DNA intercalation 348, 349, 440
excision repair
BER, base excision, enzymes and
mechanisms 329, 331
human mismatch repair, MMR 331
NER, nucleotide excision, enzymes
and mechanisms 330
short-patch repair 330
exon/intron boundary
splice sites 265
exons 210, 220, 264
exosome 273
export
RNA 280fingerprinting
in biotechnology 181
flavine adenine dinucleotide
(FAD) 112, 407
Flemming, W.
chromatin 2
fluorescence 429–430fluorescence resonance energy
transfer, FRET 159, 429–430
5-fluoro-2-deoxyuridine
error-prone PCR 191
5-fluorouracil
structure 93, 127
thymidylate synthase inhibitor 298
Fodor, S. 185
footprinting 203–204
dimethyl sulfate 204
Fenton’s reagent 204
four-stranded DNA
structure 52–55, 375
Franklin, R.
DNA structure 6
furanose ring
nucleoside structure 14
NMR analysis 436G tetrad
circular dichroism 431
gel electrophoresis
horizontal agarose
DNA separation 443
pulsed-field electrophoresis
large DNA separation 443
gene – single copy 213
gene assembly 177
gene cloning 170
gene duplication 215
gene expression
control 224–231, 391
G-tetrad regulation 379
gene families 213
gene manipulation 173
gene mutagenesis 188–192
gene sequence
overlapping frame 288
small RNA 283
gene structure 210–212
complex 211
eukaryotic 211
gene synthesis 9, 147, 177
gene therapy 192
genetic code 273, 274
genetic map 223
genome
size by species 216
glycosylic bond 78
anomeric control 84
torsion angle
NMR analysis 436
syn-, anti-21–22
glycosylic bond cleavage
DNA repair 329
GMP
biosynthesis 118
G-quartet, G-tetrad 256, 375–377
gRNA
guide RNA 271, 282