Multiphase Bioreactor Design

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Ar area reactor m^2


concentration component in phase j mol/m^3

substrate concentration in medium phase at t=0 mol/m^3

Di diffusion coefficient component m^2 /s


dbead gel bead diameter m


ddrop droplet diameter m


dnoz nozzle diameter m


Fo dimensionless time —


g gravity constant m^2 /s


Hbed height fluidised bed m


Ht height of one medium tank m


Ht,i height of disperse phase tank m


K overall mass transfer coefficient water/droplet


Km michaelis-menten constant mol/m^3


Kbead,i mass transfer coefficient component i water/gel bead


mass transfer coefficient interface droplet/bulk droplet

mass transfer coefficient bulk water/interface droplet

N_dis number of tanks in disperse phase per one medium tank —


m distribution coefficient organic/water —


Rp gel bead radius m


r space-coordinate in gel bead m


t time s


Uc medium phase flux m^3 /(m^2 s)


Ud organic solvent flux m^3 /(m^2 s)


Vr reactor volume m^3


V∞ terminal rise velocity droplet m/s


vmax maximum substrate conversion rate mol/(gcats)


vwp slip velocity water particle m/s


vwo slip velocity water droplet m/s


X concentration biocatalyst gcat/m^3


dimensionless concentration component in phase j —

Design of liquid-liquid-solid fluidised-bed bioreactors 379
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