115
- Ellison GM, Vicinanza C, Smith AJ, Aquila I, Leone A, Waring CD, et al. Adult c-kit(pos)
cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair.
Cell. 2013;154:827–42. - Oh H, Bradfute SB, Gallardo TD, Nakamura T, Gaussin V, Mishina Y, et al. Cardiac progenitor
cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl
Acad Sci U S A. 2003;100:12313–8. - Matsuura K, Nagai T, Nishigaki N, Oyama T, Nishi J, Wada H, et al. Adult cardiac Sca-1-
positive cells differentiate into beating cardiomyocytes. J Biol Chem. 2004;279:11384–91. - Martin CM, Meeson AP, Robertson SM, Hawke TJ, Richardson JA, et al. Persistent expression
of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing
and adult heart. Dev Biol. 2004;265:262–75. - Moretti A, Caron L, Nakano A, Lam JT, Bernshausen A, Chen Y, et al. Multipotent embryonic
isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell.
2006;127:1151–65. - Pandur P, Sirbu IO, Kühl SJ, Philipp M, Kühl M. Islet1-expressing cardiac progenitor cells: a
comparison across species. Dev Genes Evol. 2013;223:117–29. - Messina E, De Angelis L, Frati G, Morrone S, Chimenti S, Fiordaliso F, et al. Isolation and
expansion of adult cardiac stem cells from human and murine heart. Circ Res. 2004;95:
911–21. - Smith RR, Barile L, Cho HC, Leppo MK, Hare JM, Messina E, et al. Regenerative potential of
cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens.
Circulation. 2007;115:896–908. - Wessels A, Pérez-Pomares JM. The epicardium and epicardially derived cells (EPDCs) as
cardiac stem cells. Anat Rec A Discov Mol Cell Evol Biol. 2004;276:43–57. - Chong JJ, Chandrakanthan V, Xaymardan M, Asli NS, Li J, Ahmed I, et al. Adult cardiac-
resident MSC-like stem cells with a proepicardial origin. Cell Stem Cell. 2011;9:527–40. - Anversa P, Kajstura J, Leri A, Bolli R. Life and death of cardiac stem cells: a paradigm shift in
cardiac biology. Circulation. 2006;113:1451–63. - Hsieh PC, Segers VF, Davis ME, MacGillivray C, Gannon J, Molkentin JD, et al. Evidence
from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes
after injury. Nat Med. 2007;13:970–4. - Chan SS, Shueh YZ, Bustamante N, Tsai SJ, Wu HL, Chen JH, et al. Genetic fate-mapping for
studying adult cardiomyocyte replenishment after myocardial injury. Meth Mol Biol.
2010;660:201–11. - Malliaras K, Zhang Y, Seinfeld J, Galang G, Tseliou E, Cheng K, Sun B, et al. Cardiomyocyte
proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocar-
dial infarction in the adult mouse heart. EMBO Mol Med. 2013;5:191–209. - Uchida S, De Gaspari P, Kostin S, Jenniches K, Kilic A, Izumiya Y, et al. Sca1-derived cells are
a source of myocardial renewal in the murine adult heart. Stem Cell Rep. 2013;1:397–410. - Senyo SE, Steinhauser ML, Pizzimenti CL, Yang VK, Cai L, Wang M, et al. Mammalian heart
renewal by pre-existing cardiomyocytes. Nature. 2013;493:433–6. - Ali SR, Hippenmeyer S, Saadat LV, Luo L, Weissman IL, Ardehali R. Existing cardiomyocytes
generate cardiomyocytes at a low rate after birth in mice. Proc Natl Acad Sci U S A. 2014;
111:8850–5. - Van Berlo JH, Kanisicak O, Maillet M, Vagnozzi RJ, Karch J, Lin SC, et al. c-kit+ cells mini-
mally contribute cardiomyocytes to the heart. Nature. 2014;509:337–41. - Dawn B, Stein AB, Urbanek K, Rota M, Whang B, Rastaldo R, et al. Cardiac stem cells deliv-
ered intravascularly traverse the vessel barrier, regenerate infarcted myocardium, and improve
cardiac function. Proc Natl Acad Sci U S A. 2005;102:3766–71. - Bearzi C, Rota M, Hosoda T, Tillmanns J, Nascimbene A, De Angelis A, et al. Human cardiac
stem cells. Proc Natl Acad Sci U S A. 2007;104:14068–73. - Tang XL, Rokosh G, Sanganalmath SK, Yuan F, Sato H, Mu J, et al. Intracoronary administra-
tion of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old
infarction. Circulation. 2010;121:293–305.
7 The Emerging Role of Cardiac Stem Cells in Cardiac Regeneration