Drug Metabolism in Drug Design and Development Basic Concepts and Practice

P

P

13

13

15

15

20

20

18a,b,c

10

11

21 1

6

2

4 5

17a,b,c

HPLC time (min)

CPM

Monkey

0

200

400

600

800

1000

0.00 10.00 20.00 30.00 40.00 50.00 60.00 70.00

P

P

13

13

15

15

20

20

18a,b,c

18a,b,c

10

17a,b,c

Rat

0

2000

4000

6000

8000

0.00 10.00 20.00 30.00 40.00 50.00 60.00 70.00

0

100

200

300

400

500

0.00 10.00 20.00 30.00 40.00 50.00 60.00 70.00

P

13

20 15

18a,b,c

10

Human

FIGURE 18.3 Radiochromatograms of pooled bile samples after oral administration of

[^14 C]muraglitazar to rats, monkeys, and humans (1, 2, 3...p= M1, M2, M3 ....parent)

DATA PRESENTATION USING METABOLISM OF [^14 C]MURAGLITAZAR 593