TABLE 3.3 (
Continued
)
Isoenzyme
Endogenous substrates
Reported
Km
Drug or xenobiotic
substrates
Inducers
Inhibitors
2-hydroxy, 3- hydroxy,and 4- hydroxy biphenyl,buprenorphine (low),morphine (low), naloxone,naltrexone, ciprofibrate,diflunisal, diphenylamine,furosemide, mycophenolicacid (high), phenolphthalein,propofol, valproic acid,nandrolone, 1-methyl- 5 a
-androst-1-en-17
b-ol-
3-one (metabolite ofmetenolone), 5
a-androstane-
3 a
,17
b-diol (metabolite
of testosterone), (
)-
epigallocatechin gallate(tea phenol), SN-38(low)[metabolite of irinotecan],troglitazone (moderate), raloxifene(both 6
b- and 4
0 - b
-glucuronides),
querceten, luteolin
Entecapone: 10
mM
(Lautala, 2000)
UGT1A9/8
Retinoic acid,
thyroxine (T4),tri-iodothyronine(T3; minor),4-hydroxyestrone,4-hydroxyestradiol(major)
Planar phenols:
Phenol,
acetaminophen,2-hydroxybiphenyl,4-iodophenol,4-propylphenol,4-isopropylphenol(low), 4-ethylphenol,
TCDD,
tetrabutylhydroquinone,clofibric acid
High
concentrationsof propofol
50