Drug Metabolism in Drug Design and Development Basic Concepts and Practice

3-ethylphenol,4-methylphenol,4-nitrophenol,4-

tert

-butylphenol

(low), methylsalicylate,salicylate, mono(ethylhexyl)phthalate, BHA, BHT, vanillin,7-hydroxycoumarin,4-hydroxycoumarin(low), 4-methylumbelliferone

Bulky phenols:

phenol red,

phenolphthalein,fluorescein

Simple catechols: octyl

gallate

, propyl gallate

Primary amines:

4-aminobiphenyl

Xenobiotics:

acetaminophen,

p-HPPH (phenytoin metabolite),retigabine fenofibric acid,gemfibrozil, ciprofibric acid,clofibric acid, troglitazone(10-fold lower activity thanfibrates), SN-38(active metabolite of irinotecan),mycophenolic acid,

propfol

,

atenolol, labetolol,metoprolol, pindolol, propranolol,diflunisal, fenoprofen,

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