TABLE 3.3 (
Continued
)
Isoenzyme
Endogenous substrates
Reported
Km
Drug or xenobiotic
substrates
Inducers
Inhibitors
ibuprofen, ketoprofen,mefenamic acid,naproxen (low activityagainst all NSAIDs),bumetanide, furosemide,(dapsone), ethinylestradiol -minor),dobutamine, dopamine,levodopa, carbidopa,entacapone,
R
–oxazepam,
emodin, chrysin,7-hydroxyflavone, galangin,naringenin, quercetincarveol, nopol, citronellol,6-hydroxychrysene
UGT1A10
2-OH-estrone (low),
4-OH estrone (low),dihydrotestosterone,testosterone
Alizarin, anthraflavic acid,
apigenin, Benzo(a)pyrene-t-7,8-dihydrodiol (7
R- and
8 S
-glucuronides, high affinity),
emodin, fisetin, genistein,naringenin, quercetin,quinalizarin, 4-methylumbelliferone,scopoletin, carvacrol, eugenol,mycophenolic acid, 17
b-methyl-
5 b
–androst-4-ene-3
a,17
a-diol
(metabolite of metadienone),nandrolone, 1-methyl-5
a-androst-
1-en-17
b–ol-3-one (metabolite
of metenolone), 5
a-androstane-3
a,
17
b-diol (metabolite of testosterone),
SN-38 (minor), raloxifene(4
0 - b
-glucuronide only)
52