20 R. Macri, M. Costilla, A. Klecha et al.
strategies to correct the epigenetic alterations in the DNA and the histones,
particularly those affecting the cell cycle regulatory genes seems to be one of
the paths for the prognosis and treatment of cancer.
Figure 1. Epigenetic alterations such as the methylation of DNA or modifications in
histones silence transcription of the GST and promote tumorigenesis.
REFERENCES
[1] Tollefsbol, T.O., 2004. Methods of epigenetic analysis. Methods Mol.
Biol. 287, 1-8.
[2] Wang, H., Cao, R., Xia, L., Erdjument-Bromage, H., Borchers, C.,
Tempst, P., Zhang, Y., 2001. Purification and functional characterization
of a histone H3-lysine 4 - specific methyltransferase. Mol. Cell 8(6),
1207 - 1217.
[3] Robertson, K. D., 2001. DNA methylation, methyltransferases and
cancer. Oncogene 20, 3139-3155.