Epigenetic Modifications in Tumor Suppressor Genes (TSG) 21[4] Okano, M., Bell, D. W., Haber, D. A., Li, E., 1999. Dnmt3a and Dnmt3b
are essential for de novo methylation and mammalian development. Cell
99, 247-257.
[5] Volodko, N., Gordon, M., Salla, M., Ghazaleh, H.A., Baksh, S., 2014.
RASSF tumor suppressor gene family: biological functions and
regulation. FEBS Lett. 588(16), 2671-2684.
[6] Tapia, T., Smalley, S.V., Kohen, P., Muñoz, A., Solis, L.M., Corvalan,
A., Faundez, P., Devoto, L., Camus, M., Alvarez, M., Carvallo, P., 2008.
Promoter hypermethylation of BRCA1 correlates with absence of
expression in hereditary breast cancer tumors. Epigenetics 3(3), 157-
163.
[7] Alvarez, C., Tapia, T., Cornejo, V., Fernandez, W., Muñoz, A., Camus,
M., Alvarez, M., Devoto, L., Carvallo, P., 2013. Silencing of tumor
suppressor genes RASSF1A, SLIT2, and WIF1 by promoter
hypermethylation in hereditary breast cancer. Mol. Carcinog. 52(6), 475-
487.
[8] Dreijerink, K., Braga, E., Kuzmin, I., Geil, L., Duh, F.M., Angeloni, D.,
Zbar, B., Lerman, M.I., Stanbridge, E.J., Minna, J.D., Protopopov, A.,
Li, J., Kashuba, V., Klein, G., Zabarovsky, E.R., 2001. The candidate
tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is
involved in kidney tumorigenesis. Proc. Natl. Acad. Sci. 98(13), 7504-
7509.
[9] Papadopoulou, E., Davilas, E., Sotiriou, V., Georgakopoulos, E.,
Georgakopoulou, S., Koliopanos, A., Aggelakis, F., Dardoufas, K.,
Agnanti, N.J., Karydas, I., Nasioulas, G., 2006. Cell-free DNA and RNA
in plasma as a new molecular marker for prostate and breast cancer. Ann.
N.Y. Acad. Sci. 1075, 235-243.
[10] Martínez-Cruz, A.B., Santos, M., Lara, M.F., Segrelles, C., Ruiz, S.,
Moral, M., Lorz, C., García-Escudero, R., Paramio, J.M., 2008.
Spontaneous squamous cell carcinoma induced by the somatic
inactivation of retinoblastoma and Trp53 tumor suppressors. Cancer
Res. 68(3), 683 - 692.
[11] Tan, S.X., Hu, R.C., Liu JJ, et al. Methylation of PRDM2, PRDM5 and
PRDM16 genes in lung cancer cells. Int. J. Clin. Exp. Pathol. 2014;7(5):
2305 - 2311.