SR, Carling D, Gamblin SJ (2013) Structural
basis of AMPK regulation by small molecule
activators. Nat Commun 4:3017
- Calabrese MF, Rajamohan F, Harris MS, Cas-
pers NL, Magyar R, Withka JM, Wang H, Bor-
zilleri KA, Sahasrabudhe PV, Hoth LR,
Geoghegan KF, Han S, Brown J, Subashi TA,
Reyes AR, Frisbie RK, Ward J, Miller RA,
Landro JA, Londregan AT, Carpino PA,
Cabral S, Smith AC, Conn EL, Cameron KO,
Qiu X, Kurumbail RG (2014) Structural basis
for AMPK activation: natural and synthetic
ligands regulate kinase activity from opposite
poles by different molecular mechanisms.
Structure 22:1161–1172 - Langendorf CG, Ngoei KR, Scott JW, Ling
NX, Issa SM, Gorman MA, Parker MW,
Sakamoto K, Oakhill JS, Kemp BE (2016)
Structural basis of allosteric and synergistic
activation of AMPK by furan-2-phosphonic
derivative C2 binding. Nat Commun 7:10912 - Salatto CT, Miller RA, Cameron KO,
Cokorinos E, Reyes A, Ward J, Calabrese MF,
Kurumbail RG, Rajamohan F, Kalgutkar AS,
Tess DA, Shavnya A, Genung NE, Edmonds
DJ, Jatkar A, Maciejewski BS, Amaro M,
Gandhok H, Monetti M, Cialdea K,
Bollinger E, Kreeger JM, Coskran TM, Opsahl
AC, Boucher GG, Birnbaum MJ, DaSilva-
Jardine P, Rolph T (2017) Selective activation
of AMPK beta1-containing isoforms improves
kidney function in a rat model of diabetic
nephropathy. J Pharmacol Exp Ther
361:303–311
- Li X, Wang L, Zhou XE, Ke J, de Waal PW,
Gu X, Tan MH, Wang D, Wu D, Xu HE,
Melcher K (2015) Structural basis of AMPK
regulation by adenine nucleotides and glyco-
gen. Cell Res 25:50–66 - Leung L-H, Yao X-J, Wong KW, Liu L, Chen X
(2016) Identification of a new AMPK activator
for treatment of lung cancer. US Patent
US9364469(B1) - Woods A, Dickerson K, Heath R, Hong SP,
Momcilovic M, Johnstone SR, Carlson M, Car-
ling D (2005) Ca2þ/calmodulin-dependent
protein kinase kinase-beta acts upstream of
AMP-activated protein kinase in mammalian
cells. Cell Metab 2:21–33 - Xiao B, Hubbard JA, Gamblin SJ (2017) Struc-
ture of full length human AMPK
(non-phosphorylated at t-loop) in complex
with a small molecule activator, a benzimid-
azole derivative (991). Protein Database: 5ISO
14 Julia A. Hubbard et al.